Logo Tours
  • Weisinger J, Bouzid R, Fadlallah J, Barbet C, Provot F, Poullin P, Neel A, Marie M, Rieu V, Kanouni T, Moranne O, Azoulay E, Marjanovic Z, Corre E, Joly AC, Baylatry MT, Joly BS, Veyradier A, Coppo P; French National Center for Thrombotic Microangiopathies (CNR‐MAT). Efficacy and Safety of Obinutuzumab in Immune-Mediated Thrombotic Thrombocytopenic Purpura. Am J Hematol. 2025 Feb;100(2):350-353. doi: 10.1002/ajh.27550. Epub 2024 Dec 12. PMID: 39668454; PMCID: PMC11705199.
  • Coppo P, Bubenheim M, Azoulay E, Galicier L, Malot S, Bigé N, Poullin P, Provôt F, Martis N, Presne C, Moranne O, Benainous R, Dossier A, Seguin A, Hié, M, Wynckel A, Delmas Y, Augusto JF, Perez P, Rieu V, Barbet C, Lhote F, Ulrich, M, Rumpler AC, de Witte S, Krummel T, Veyradier A, Benhamou Y. A regimen with caplacizumab, immunosuppression, and plasma exchange prevents unfavorable outcomes in immune-mediated TTP. Blood. 2021 Feb 11;137(6):733-742. doi: 10.1182/blood.2020008021. PMID: 33150928; PMCID: PMC7986049.
  • Fakhouri F, Fila M, Provôt F, Delmas Y, Barbet C, Châtelet V, Rafat C, Cailliez M, Hogan J, Servais A, Karras A, Makdassi R, Louillet F, Coindre JP, Rondeau E, Loirat C, Frémeaux-Bacchi V. Pathogenic Variants in Complement Genes and Risk of Atypical Hemolytic Uremic Syndrome Relapse after Eculizumab Discontinuation. Clin J Am Soc Nephrol. 2017 Jan 6;12(1):50-59. doi: 10.2215/CJN.06440616. Epub 2016 Oct 31. PMID: 27799617; PMCID: PMC5220663.
  • Boulestreau R, Lorthioir A, Dreau H, Persu A, Cremer A, Tharaux PL, Rubin S, Maier B, Mazighi M, Seris A, Paques M, Bonnin S, Halimi JM, Debeugny S, Gosse P; HAMA investigators. Baseline characteristics of the first 302 patients included for acute malignant hypertension crisis in the prospective multidisciplinary HAMA cohort. J Hypertens. 2024 Dec 1;42(12):2131-2138. doi: 10.1097/HJH.0000000000003851. Epub 2024 Oct 7. PMID: 39351849.
  • Joseph A, Harel S, Mesnard L, Rafat C, Knapp S, Rumpler A, Philipponnet C, Barba C, Rebibou JM, Buob D, Hertig A, Vargaftig J, Halimi JM, Arnulf B, Bretaud AS, Joly B, Grangé S, Coppo P. Carfilzomib-associated thrombotic microangiopathy: clinical features and outcomes. Nephrol Dial Transplant. 2024 Nov 27;39(12):2067-2078. doi: 10.1093/ndt/gfae096. PMID: 38658194.
  • Maisons V, Duval A, Mesnard L, Frimat M, Fakhouri F, Grangé S, Servais A, Cartery C, Fauchier L, Coppo P, Titeca-Beauport D, Fage N, Delmas Y, Quérard AH, Seret G, Bobot M, Le Quintrec M, Ville S, von Tokarski F, Chauvet S, Wynckel A, Martins M, Schurder J, Barbet C, Sautenet B, Gatault P, Caillard S, Vuiblet V, Halimi JM; MATRIX Consortium Group. Assessment of epidemiology and outcomes of adult patients with kidney-limited thrombotic microangiopathies. Kidney Int. 2024 May;105(5):1100-1112. doi: 10.1016/j.kint.2024.02.014. Epub 2024 Feb 29. PMID: 38431217.
  • Le Tilly O, Gatault P, Semlali S, Sberro-Soussan R, Passot C, Bertrand D, Desvignes C, Caillard S, Paintaud G, Halimi JM, Ternant D. Eculizumab dose tapering should take into account the nonlinearity of its pharmacokinetics. Br J Clin Pharmacol. 2024 May;90(5):1312-1321. doi: 10.1111/bcp.16019. Epub 2024 Feb 19. PMID: 38373846.
  • Robert T, Greillier S, Torrents J, Raymond L, Dancer M, Jourde-Chiche N, Halimi JM, Burtey S, Béroud C, Mesnard L. Diagnosis of Kidney Diseases of Unknown Etiology Through Biopsy-Genetic Analysis. Kidney Int Rep. 2023 Jul 22;8(10):2077-2087. doi: 10.1016/j.ekir.2023.07.003. PMID: 37850010; PMCID: PMC10577324.
  • Von Tokarski F, Fillon A, Maisons V, Thoreau B, Bayer G, Gatault P, Longuet H, Sautenet B, Buchler M, Vigneau C, Fakhouri F, Halimi JM. Thrombotic microangiopathies after kidney transplantation in modern era: nosology based on chronology. BMC Nephrol. 2023 Sep 20;24(1):278. doi: 10.1186/s12882-023-03326-8. PMID: 37730583; PMCID: PMC10512637.
  • Largeau B, Thoreau B, Grangé S, Jonville-Béra AP, Halimi JM. Thrombotic microangiopathy associated with anticancer and immune system targeting drugs: New insights from real-world data using the WHO pharmacovigilance database. J Intern Med. 2023 Nov;294(5):665-678. doi: 10.1111/joim.13703. Epub 2023 Aug 4. PMID: 37538031.
  • Neuman L, Joseph A, Bouzid R, Lescroart M, Mariotte E, Ederhy S, Tuffet S, Baudel JL, Benhamou Y, Galicier L, Grangé S, Provôt F, Neel A, Pène F, Delmas Y, Presne C, Poullin P, Wynckel A, Perez P, Barbet C, Halimi JM, Chatelet V, Rebibou JM, Ojeda-Uribe M, Vigneau C, Mesnard L, Veyradier A, Azoulay E, Coppo P, Chabriat H; participants to the Prospective Multicenter MATRISK study. Predictors of acute ischemic cerebral lesions in immune-mediated thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. J Neurol. 2023 Oct;270(10):5023-5033. doi: 10.1007/s00415-023-11830-y. Epub 2023 Jul 1. PMID:
  • Halimi JM, de Fréminville JB, Gatault P, Bisson A, Sautenet B, Maisons V, Vigny P, Angoulvant D, Fauchier L. Characteristics and Prognosis of Patients With Hypertensive Encephalopathy: A French Nationwide Cohort Study. Hypertension. 2023 Aug;80(8):1716-1727. doi: 10.1161/HYPERTENSIONAHA.123.21226. Epub 2023 Jun 7. PMID: 37283073.
  • Kaczmarek M, Halimi JM, de Fréminville JB, Gatault P, Gueguen J, Goin N, Longuet H, Barbet C, Bisson A, Sautenet B, Herbert J, Buchler M, Fauchier L. A Universal Bleeding Risk Score in Native and Allograft Kidney Biopsies: A French Nationwide Cohort Study. J Clin Med. 2023 May 17;12(10):3527. doi: 10.3390/jcm12103527. PMID: 37240634; PMCID: PMC10219527.
  • Boulestreau R, Lorthioir A, Persu A, Sarafidis P, Cremer A, Tharaux PL, Rubin S, Maier B, Mazighi M, Paques M, Bonnin S, Dreau H, Debeugny S, Halimi JM, Gosse P. Revisiting malignant hypertension: rationale and design of the ‘HAMA cohort’, on behalf of the ESH working group ‘hypertension and the kidney’. J Hypertens. 2023 Mar 1;41(3):453-458. doi: 10.1097/HJH.0000000000003357. Epub 2023 Jan 9. PMID: 36719959.
  • Joseph A, Brilland B, Burguet L, Eloit M, Fage N, Augusto JF, Delmas Y, Veyradier A, Halimi JM, Coppo P. Predictive Scores for Early Identification of Immune-Mediated Thrombotic Thrombocytopenic Purpura: Room for Improvement? Kidney Int Rep. 2022 Sep 23;7(11):2541-2542. doi: 10.1016/j.ekir.2022.09.016. PMID: 36531867; PMCID: PMC9751677.
  • Bureau C, Jamme M, Schurder J, Bobot M, Robert T, Couturier A, Karras A, Halimi JM, Bellenfant X, Rondeau E, Mesnard L. Nephrosclerosis in young patients with malignant hypertension. Nephrol Dial Transplant. 2023 Jul 31; 38(8):1848-1856. doi: 10.1093/ndt/gfac324. PMID: 36477902.
  • Halimi JM, Al-Dakkak I, Anokhina K, Ardissino G, Licht C, Lim WH, Massart A, Schaefer F, Walle JV, Rondeau E. Clinical characteristics and outcomes of a patient population with atypical hemolytic uremic syndrome and malignant hypertension: analysis from the Global aHUS registry. J Nephrol. 2023 Apr;36(3):817-828. doi: 10.1007/s40620-022-01465-z. Epub 2022 Sep 24. PMID: 36152218; PMCID: PMC10090001. 
  • Joseph A, Eloit M, Azoulay E, Kaplanski G, Provot F, Presne C, Wynckel A, Grangé S, Rondeau É, Pène F, Delmas Y, Lautrette A, Barbet C, Mousson C, Coindre JP, Perez P, Jamme M, Augusto JF, Poullin P, Jacobs F, El Karoui K, Vigneau C, Ulrich M, Kanouni T, Le Quintrec M, Hamidou M, Ville S, Charvet-Rumpler A, Ojeda-Uribe M, Godmer P, Fremeaux-Bacchi V, Veyradier A, Halimi JM, Coppo P. Immune-mediated thrombotic thrombocytopenic purpura prognosis is affected by blood pressure. Res Pract Thromb Haemost. 2022 May 18;6(4):e12702. doi: 10.1002/rth2.12702. PMID: 35599703; PMCID: PMC9115975.
  • Halimi JM, Thoreau B, von Tokarski F, Bauvois A, Gueguen J, Goin N, Barbet C, Cloarec S, Mérieau E, Lachot S, Garot D, Lemaignen A, Gyan E, Perrotin F, Pouplard C, Maillot F, Gatault P, Sautenet B, Rusch E, Frémeaux-Bacchi V, Vigneau C, Bayer G, Fakhouri F. What is the impact of blood pressure on neurological symptoms and the risk of ESKD in primary and secondary thrombotic microangiopathies based on clinical presentation: a retrospective study. BMC Nephrol. 2022 Jan 20;23(1):39. doi: 10.1186/s12882-022-02672-3. PMID: 35057750; PMCID: PMC8781095.
  • Halimi JM, Gatault P, Longuet H, Barbet C, Goumard A, Gueguen J, Goin N, Sautenet B, Herbert J, Bisson A, Fauchier L. Major Bleeding of Transjugular Native Kidney Biopsies. A French Nationwide Cohort Study. Kidney Int Rep. 2021 Jul 17;6(10):2594-2603. doi: 10.1016/j.ekir.2021.07.011. PMID: 34622099; PMCID: PMC8484497.
  • Thoreau B, von Tokarski F, Bauvois A, Bayer G, Barbet C, Cloarec S, Mérieau E, Lachot S, Garot D, Bernard L, Gyan E, Perrotin F, Pouplard C, Maillot F, Gatault P, Sautenet B, Rusch E, Frémeaux-Bacchi V, Vigneau C, Fakhouri F, Halimi JM. Infection in Patients with Suspected Thrombotic Microangiopathy Based on Clinical Presentation. Clin J Am Soc Nephrol. 2021 Sep;16(9):1355-1364. doi: 10.2215/CJN.17511120. PMID: 34497111; PMCID: PMC8729578.
  • Halimi JM, Gatault P, Longuet H, Barbet C, Bisson A, Sautenet B, Herbert J, Buchler M, Grammatico-Guillon L, Fauchier L. Major Bleeding and Risk of Death after Percutaneous Native Kidney Biopsies: A French Nationwide Cohort Study. Clin J Am Soc Nephrol. 2020 Nov 6;15(11):1587-1594. doi: 10.2215/CJN.14721219. Epub 2020 Oct 15. Erratum in: Clin J Am Soc Nephrol. 2021 Aug;16(8):1261. doi: 10.2215/CJN.08200621. PMID: 33060158; PMCID: PMC7646233.
  • Prevel R, Roubaud-Baudron C, Gourlain S, Jamme M, Peres K, Benhamou Y, Galicier L, Azoulay E, Poullin P, Provôt F, Maury E, Presne C, Hamidou M, Saheb S, Wynckel A, Servais A, Girault S, Delmas Y, Chatelet V, Augusto JF, Mousson C, Perez P, Halimi JM, Kanouni T, Lautrette A, Charvet-Rumpler A, Deligny C, Chauveau D, Veyradier A, Coppo P. Immune thrombotic thrombocytopenic purpura in older patients: prognosis and long-term survival. Blood. 2019 Dec 12;134(24):2209-2217. doi: 10.1182/blood.2019000748. PMID: 31530564.
  • Boulestreau R, Cremer A, Lorthioir A, Rubin S, Tharaux PL, Persu A, Halimi JM, Gosse P. L’hypertension artérielle maligne, un futur prometteur [Malignant hypertension: A bright future]. Presse Med. 2019 Dec;48(12):1439-1444. French. doi: 10.1016/j.lpm.2019.07.007. Epub 2019 Aug 27. PMID: 31471092.
  • Le Clech A, Simon-Tillaux N, Provôt F, Delmas Y, Vieira-Martins P, Limou S, Halimi JM, Le Quintrec M, Lebourg L, Grangé S, Karras A, Ribes D, Jourde-Chiche N, Rondeau E, Frémeaux-Bacchi V, Fakhouri F. Atypical and secondary hemolytic uremic syndromes have a distinct presentation and no common genetic risk factors. Kidney Int. 2019 Jun;95(6):1443-1452. doi: 10.1016/j.kint.2019.01.023. Epub 2019 Mar 15. PMID: 30982675.
  • El Karoui K, Boudhabhay I, Petitprez F, Vieira-Martins P, Fakhouri F, Zuber J, Aulagnon F, Matignon M, Rondeau E, Mesnard L, Halimi JM, Frémeaux-Bacchi V. Impact of hypertensive emergency and rare complement variants on the presentation and outcome of atypical hemolytic uremic syndrome. Haematologica. 2019 Dec;104(12):2501-2511. doi: 10.3324/haematol.2019.216903. Epub 2019 Mar 19. PMID: 30890598; PMCID: PMC6959192. 
  • Bayer G, von Tokarski F, Thoreau B, Bauvois A, Barbet C, Cloarec S, Mérieau E, Lachot S, Garot D, Bernard L, Gyan E, Perrotin F, Pouplard C, Maillot F, Gatault P, Sautenet B, Rusch E, Buchler M, Vigneau C, Fakhouri F, Halimi JM. Etiology and Outcomes of Thrombotic Microangiopathies. Clin J Am Soc Nephrol. 2019 Apr 5;14(4):557-566. doi: 10.2215/CJN.11470918. Epub 2019 Mar 12. PMID: 30862697; PMCID: PMC6450353.
  • Jestin M, Benhamou Y, Schelpe AS, Roose E, Provôt F, Galicier L, Hié M, Presne C, Poullin P, Wynckel A, Saheb S, Deligny C, Servais A, Girault S, Delmas Y, Kanouni T, Lautrette A, Chauveau D, Mousson C, Perez P, Halimi JM, Charvet-Rumpler A, Hamidou M, Cathébras P, Vanhoorelbeke K, Veyradier A, Coppo P; French Thrombotic Microangiopathies Reference Center. Preemptive rituximab prevents long-term relapses in immune-mediated thrombotic thrombocytopenic purpura. Blood. 2018 Nov 15;132(20):2143-2153. doi: 10.1182/blood-2018-04-840090. Epub 2018 Sep 10. PMID: 30201758.
  • Garnier A, Brochard K, Kwon T, Sellier-Leclerc AL, Lahoche A, Launay EA, Nobili F, Caillez M, Taque S, Harambat J, Michel-Bourdat G, Guigonis V, Fila M, Cloarec S, Djamal-Dine D, de Parscaux L, Allard L, Salomon R, Ulinski T, Frémeaux-Bacchi V, Morin C, Olivier-Abbal P, Colineaux H, Auriol F, Arnaud C, Kieffer I, Brusq C. Efficacy and Safety of Eculizumab in Pediatric Patients Affected by Shiga Toxin-Related Hemolytic and Uremic Syndrome: A Randomized, Placebo-Controlled Trial. J Am Soc Nephrol. 2023 Sep 1;34(9):1561-1573. doi: 10.1681/ASN.0000000000000182. Epub 2023 Jun 12. PMID: 37303085; PMCID: PMC10482062.
  • Chauvet S, Hauer JJ, Petitprez F, Rabant M, Martins PV, Baudouin V, Delmas Y, Jourde-Chiche N, Cez A, Ribes D, Cloarec S, Servais A, Zaidan M, Daugas E, Delahousse M, Wynckel A, Ryckewaert A, Sellier-Leclerc AL, Boyer O, Thervet E, Karras A, Smith RJH, Frémeaux-Bacchi V. Results from a nationwide retrospective cohort measure the impact of C3 and soluble C5b-9 levels on kidney outcomes in C3 glomerulopathy. Kidney Int. 2022 Oct;102(4):904-916. doi: 10.1016/j.kint.2022.05.027. Epub 2022 Jun 22. PMID: 35752323; PMCID: PMC10588728.
  • Chauvet S, Berthaud R, Devriese M, Mignotet M, Vieira Martins P, Robe-Rybkine T, Miteva MA, Gyulkhandanyan A, Ryckewaert A, Louillet F, Merieau E, Mestrallet G, Rousset-Rouvière C, Thervet E, Hogan J, Ulinski T, Villoutreix BO, Roumenina L, Boyer O, Frémeaux-Bacchi V. Anti-Factor B Antibodies and Acute Postinfectious GN in Children. J Am Soc Nephrol. 2020 Apr;31(4):829-840. doi: 10.1681/ASN.2019080851. Epub 2020 Feb 7. PMID: 32034108; PMCID: PMC7191928.
  • Zuber J, Frimat M, Caillard S, Kamar N, Gatault P, Petitprez F, Couzi L, Jourde-Chiche N, Chatelet V, Gaisne R, Bertrand D, Bamoulid J, Louis M, Sberro Soussan R, Navarro D, Westeel PF, Frimat L, Colosio C, Thierry A, Rivalan J, Albano L, Arzouk N, Cornec-Le Gall E, Claisse G, Elias M, El Karoui K, Chauvet S, Coindre JP, Rerolle JP, Tricot L, Sayegh J, Garrouste C, Charasse C, Delmas Y, Massy Z, Hourmant M, Servais A, Loirat C, Fakhouri F, Pouteil-Noble C, Peraldi MN, Legendre C, Rondeau E, Le Quintrec M, Frémeaux-Bacchi V. Use of Highly Individualized Complement Blockade Has Revolutionized Clinical Outcomes after Kidney Transplantation and Renal Epidemiology of Atypical Hemolytic Uremic Syndrome. J Am Soc Nephrol. 2019 Dec;30(12):2449-2463. doi: 10.1681/ASN.2019040331. Epub 2019 Oct 1. PMID: 31575699; PMCID: PMC6900783.