{"id":380,"date":"2023-02-20T15:07:42","date_gmt":"2023-02-20T14:07:42","guid":{"rendered":"https:\/\/www.chu-tours.fr\/pemr-cvl\/?page_id=380"},"modified":"2024-05-31T10:38:17","modified_gmt":"2024-05-31T08:38:17","slug":"maladies-hemorragiques-constitutionnelles","status":"publish","type":"page","link":"https:\/\/www.chu-tours.fr\/pemr-cvl\/maladies-hemorragiques-constitutionnelles\/","title":{"rendered":"Maladies H\u00e9morragiques Constitutionnelles"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"380\" class=\"elementor elementor-380\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5078e3bd elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5078e3bd\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6f8b906a\" data-id=\"6f8b906a\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-7b275b69 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7b275b69\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-12eeacb9\" data-id=\"12eeacb9\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2b44a156 elementor-widget elementor-widget-image\" data-id=\"2b44a156\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 15-07-2024 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"131\" height=\"101\" src=\"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-content\/uploads\/sites\/15\/2023\/02\/logo-crmr.png\" class=\"attachment-medium size-medium wp-image-361\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-4605c9a9\" data-id=\"4605c9a9\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3abffc7e elementor-widget elementor-widget-image\" data-id=\"3abffc7e\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"283\" height=\"187\" src=\"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-content\/uploads\/sites\/15\/2023\/02\/trousseau.png\" class=\"attachment-large size-large wp-image-385\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-42e4dd7\" data-id=\"42e4dd7\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-154483ee elementor-widget elementor-widget-image\" data-id=\"154483ee\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"207\" height=\"100\" src=\"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-content\/uploads\/sites\/15\/2023\/02\/logo-mhemo.png\" class=\"attachment-medium size-medium wp-image-387\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-b92ce25 elementor-widget elementor-widget-heading\" data-id=\"b92ce25\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 15-07-2024 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-default\">Centre de Ressources et de Comp\u00e9tences Maladies H\u00e9morragiques Constitutionnelles<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1d9e705 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1d9e705\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-606ed11c\" data-id=\"606ed11c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7ae86bf9 elementor-widget elementor-widget-text-editor\" data-id=\"7ae86bf9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 15-07-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p><strong>Le Centre de r\u00e9f\u00e9rence constitutif est compos\u00e9 d\u2019une \u00e9quipe multidisciplinaire sp\u00e9cialis\u00e9e dans la prise en charge des Maladies H\u00e9morragiques Constitutionnelles<\/strong>.<\/p><p>Ses missions :<\/p><ul><li>Faciliter le diagnostic et la prise en charge des patients<\/li><li>Coordonner et participer \u00e0 des travaux de recherche (fondamentales, cliniques, \u00e9pid\u00e9miologiques)<\/li><li>Am\u00e9liorer la lisibilit\u00e9 des pathologies pour les patients<\/li><li>Etre des interlocuteurs privil\u00e9gi\u00e9s pour les associations de patients<\/li><li>Promouvoir l\u2019enseignement et la formation<\/li><li>Le centre est membre de la Fili\u00e8re de Sant\u00e9 Maladies Rares MHEMO et labellis\u00e9 \u00ab <strong>European Haemophilia Comprehensive Care Centre<\/strong> \u00bb <strong>dans le r\u00e9seau europ\u00e9en EUHANET<\/strong><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-78db2486 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"78db2486\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-3e6b22a7\" data-id=\"3e6b22a7\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3ec91a30 elementor-widget elementor-widget-image\" data-id=\"3ec91a30\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"40\" height=\"40\" src=\"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-content\/uploads\/sites\/15\/2023\/02\/uk-flag-square-icon-128-40x40-1-40x40.png\" class=\"attachment-pictogramme-home size-pictogramme-home wp-image-372\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-7a001322\" data-id=\"7a001322\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-475cbd7b elementor-widget elementor-widget-toggle\" data-id=\"475cbd7b\" data-element_type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 15-07-2024 *\/\n.elementor-toggle{text-align:start}.elementor-toggle .elementor-tab-title{font-weight:700;line-height:1;margin:0;padding:15px;border-bottom:1px solid #d5d8dc;cursor:pointer;outline:none}.elementor-toggle .elementor-tab-title .elementor-toggle-icon{display:inline-block;width:1em}.elementor-toggle .elementor-tab-title .elementor-toggle-icon svg{margin-inline-start:-5px;width:1em;height:1em}.elementor-toggle .elementor-tab-title .elementor-toggle-icon.elementor-toggle-icon-right{float:right;text-align:right}.elementor-toggle .elementor-tab-title .elementor-toggle-icon.elementor-toggle-icon-left{float:left;text-align:left}.elementor-toggle .elementor-tab-title .elementor-toggle-icon .elementor-toggle-icon-closed{display:block}.elementor-toggle .elementor-tab-title .elementor-toggle-icon .elementor-toggle-icon-opened{display:none}.elementor-toggle .elementor-tab-title.elementor-active{border-bottom:none}.elementor-toggle .elementor-tab-title.elementor-active .elementor-toggle-icon-closed{display:none}.elementor-toggle .elementor-tab-title.elementor-active .elementor-toggle-icon-opened{display:block}.elementor-toggle .elementor-tab-content{padding:15px;border-bottom:1px solid #d5d8dc;display:none}@media (max-width:767px){.elementor-toggle .elementor-tab-title{padding:12px}.elementor-toggle .elementor-tab-content{padding:12px 10px}}.e-con-inner>.elementor-widget-toggle,.e-con>.elementor-widget-toggle{width:var(--container-widget-width);--flex-grow:var(--container-widget-flex-grow)}<\/style>\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1191\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1191\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\"><em>The reference centre is composed of...<\/em><\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1191\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1191\"><p><em>The reference centre is composed of a multidisciplinary team specialised in the care of Hereditary Blood-Clotting Disorders.\u00a0 The duties of the centre are:<\/em><\/p><ul><li><em>Ensure the diagnostic and the coordination of care <\/em><\/li><li><em>Organise and participate in research projects (fundamental, clinical, epidemiological)<\/em><\/li><li><em>Improve patient knowledge<\/em><\/li><li><em>Be the primary interlocutor for Patient Associations<\/em><\/li><li><em>Promote education and training<\/em><\/li><\/ul><p><em>The centre is a member of the French National Rare Disease Network MHEMO and is labelled \u00ab\u00a0European Haemophilia Comprehensive Care Centre\u00a0\u00bb in the European network EUHANET<\/em><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-706c57af elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"706c57af\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1cce92b8\" data-id=\"1cce92b8\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4478f378 elementor-widget elementor-widget-image\" data-id=\"4478f378\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-content\/uploads\/sites\/15\/2023\/02\/pathologies-mhemo-150x150-1-150x150.png\" class=\"attachment-thumbnail size-thumbnail wp-image-384\" alt=\"\" srcset=\"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-content\/uploads\/sites\/15\/2023\/02\/pathologies-mhemo-150x150-1.png 150w, https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-content\/uploads\/sites\/15\/2023\/02\/pathologies-mhemo-150x150-1-40x40.png 40w\" sizes=\"(max-width: 150px) 100vw, 150px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">PATHOLOGIES CONCERN\u00c9ES<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4b105cf6 elementor-widget elementor-widget-toggle\" data-id=\"4b105cf6\" data-element_type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1251\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1251\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\"><span style=\"text-transform: uppercase\"><strong>Pathologies concern\u00e9es<\/strong><\/span><\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1251\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1251\"><h3>L\u2019H\u00e9mophilie<\/h3><p>L\u2019H\u00e9mophilie est une maladie h\u00e9morragique g\u00e9n\u00e9tique due \u00e0 l\u2019absence totale ou partielle d\u2019un facteur de coagulation\u00a0:<\/p><ul><li>S\u2019il s\u2019agit du facteur VIII (8) on parle d\u2019h\u00e9mophilie A<\/li><li>S\u2019il s\u2019agit du facteur F IX (9) on parle d\u2019h\u00e9mophilie B<\/li><\/ul><p>La pr\u00e9valence est d\u2019environ <strong>1\/7500<\/strong> naissances de sexe masculin pour l\u2019h\u00e9mophilie A et d\u2019<strong>1\/30000<\/strong> pour l\u2019h\u00e9mophilie B. L\u2019h\u00e9mophilie A repr\u00e9sente environ 80% des h\u00e9mophiles.<\/p><p>On compte en France environ 7500 h\u00e9mophiles\u00a0; c\u2019est la plus fr\u00e9quente des maladies h\u00e9morragiques graves.<\/p><h3>Les D\u00e9ficits Rares en Facteurs de la Coagulation<\/h3><p>Les d\u00e9ficits rares en facteur de la coagulation sont des anomalies h\u00e9r\u00e9ditaires de la coagulation qui surviennent quand un ou plusieurs facteurs de coagulation (facteurs I, II, V, V+VIII, VII, X, XI ou XIII) sont absents ou ne fonctionnent pas correctement. M\u00eame si la symptomatologie h\u00e9morragique est au premier plan, chaque d\u00e9ficit en facteur de la coagulation pr\u00e9sente des caract\u00e9ristiques biologiques et cliniques qui lui sont propres et qui doivent \u00eatre consid\u00e9r\u00e9es lors de la mise en place d\u2019une strat\u00e9gie th\u00e9rapeutique. La fr\u00e9quence, des d\u00e9ficits rares en facteurs de la coagulation est peu connue.<\/p><h3>La Maladie de Willebrand<\/h3><p>La maladie de Willebrand (MW) est une maladie \u00e0 risque h\u00e9morragique, de gravit\u00e9 variable, g\u00e9n\u00e9tique, due \u00e0 un d\u00e9faut de synth\u00e8se ou de structure, et\/ou de fonction d\u2019une prot\u00e9ine participant \u00e0 la phase initiale du processus de la coagulation (h\u00e9mostase) appel\u00e9 facteur \u00a0Von Willebrand (VWF), du nom du docteur Erik Von Willebrand, m\u00e9decin finlandais qui a d\u00e9crit la maladie en 1926, en Finlande.<\/p><p>Il existe deux grands groupes de d\u00e9ficit en VWF : quantitatif, partiel (type 1) ou total (type 3), et qualitatif (type 2) regroupant plusieurs sous-types (2A, 2B, 2M, 2N)<\/p><p>Le nombre de patients de tous types pr\u00e9sentant une symptomatologie h\u00e9morragique qui n\u00e9cessite un traitement sp\u00e9cifique a \u00e9t\u00e9 estim\u00e9 entre 1\/50 000 et 1\/8 500.<\/p><h3>Les Pathologies Plaquettaires<\/h3><p>Thrombop\u00e9nies Constitutionnelles &#8211;\u00a0 sont des pathologies rares d\u2019origine g\u00e9n\u00e9tique<\/p><p>Thrombopathies Constitutionnelles &#8211; sont des pathologies li\u00e9es \u00e0 des anomalies<\/p><p>de fonctionnement des plaquettes qui sont d\u2019origine g\u00e9n\u00e9tique<\/p><p>Plus d\u2019informations sur les maladies rares: <a href=\"http:\/\/www.mhemo.fr\" target=\"_blank\" rel=\"noopener\">www.mhemo.fr<\/a> &#8211; rubrique pathologies<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e5f2c04 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e5f2c04\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5840f700\" data-id=\"5840f700\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-612bd53b elementor-widget elementor-widget-image\" data-id=\"612bd53b\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"212\" src=\"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-content\/uploads\/sites\/15\/2023\/02\/outils-300x212-1.png\" class=\"attachment-medium size-medium wp-image-367\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">L'\u00c9QUIPE<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-69ceba34 elementor-widget elementor-widget-toggle\" data-id=\"69ceba34\" data-element_type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1771\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1771\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\"><span style=\"text-transform: uppercase\"><strong>L'\u00e9quipe<\/strong><\/span><\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1771\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1771\"><p><strong>\u00c9quipe m\u00e9dicale\u00a0<\/strong><\/p><ul><li><strong>Dr Laurent ARDILLON &#8211; M\u00e9decin biologiste &#8211; Coordonnateur du Centre<\/strong><\/li><li>Pr Yves GRUEL &#8211; M\u00e9decin H\u00e9matologiste<\/li><li>Dr Jean-Baptiste VALENTIN &#8211; M\u00e9decin biologiste<\/li><li>Pr Claire POUPLARD &#8211; Biologiste, Cheffe de service<\/li><li>Dr Eve-Anne GUERY &#8211; biologiste, responsable de secteur Biologie h\u00e9morragique<\/li><\/ul><p><strong>\u00c9quipe param\u00e9dicale<\/strong><\/p><ul><li>Mme Virginie PAY &#8211; Infirmi\u00e8re coordonnatrice<\/li><li>Mme Sylvie LEFRANCOIS &#8211; Secr\u00e9taire<\/li><li>Mme Virginie PERDONCIN &#8211; Psychologue<\/li><li>Mme Dominique LAFEVRE &#8211; Kin\u00e9sith\u00e9rapeute<\/li><li>Mme Georgiana BISOCEANU &#8211; Kin\u00e9sith\u00e9rapeute<\/li><li>M. Damien TABAUX &#8211; Attach\u00e9 de recherche clinique <\/li><\/ul><p><strong>Pharmaciens r\u00e9f\u00e9rents<\/strong><\/p><ul><li>Dr S\u00e9bastien BAUER<\/li><li>Dr Dominique BAETZ<\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7cd9a38c elementor-widget elementor-widget-accordion\" data-id=\"7cd9a38c\" data-element_type=\"widget\" data-widget_type=\"accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 15-07-2024 *\/\n.elementor-accordion{text-align:start}.elementor-accordion .elementor-accordion-item{border:1px solid #d5d8dc}.elementor-accordion .elementor-accordion-item+.elementor-accordion-item{border-top:none}.elementor-accordion .elementor-tab-title{margin:0;padding:15px 20px;font-weight:700;line-height:1;cursor:pointer;outline:none}.elementor-accordion .elementor-tab-title .elementor-accordion-icon{display:inline-block;width:1.5em}.elementor-accordion .elementor-tab-title .elementor-accordion-icon svg{width:1em;height:1em}.elementor-accordion .elementor-tab-title .elementor-accordion-icon.elementor-accordion-icon-right{float:right;text-align:right}.elementor-accordion .elementor-tab-title .elementor-accordion-icon.elementor-accordion-icon-left{float:left;text-align:left}.elementor-accordion .elementor-tab-title .elementor-accordion-icon .elementor-accordion-icon-closed{display:block}.elementor-accordion .elementor-tab-title .elementor-accordion-icon .elementor-accordion-icon-opened,.elementor-accordion .elementor-tab-title.elementor-active .elementor-accordion-icon-closed{display:none}.elementor-accordion .elementor-tab-title.elementor-active .elementor-accordion-icon-opened{display:block}.elementor-accordion .elementor-tab-content{display:none;padding:15px 20px;border-top:1px solid #d5d8dc}@media (max-width:767px){.elementor-accordion .elementor-tab-title{padding:12px 15px}.elementor-accordion .elementor-tab-title .elementor-accordion-icon{width:1.2em}.elementor-accordion .elementor-tab-content{padding:7px 15px}}.e-con-inner>.elementor-widget-accordion,.e-con>.elementor-widget-accordion{width:var(--container-widget-width);--flex-grow:var(--container-widget-flex-grow)}<\/style>\t\t<div class=\"elementor-accordion\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2091\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-2091\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><i class=\"fas fa-plus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><i class=\"fas fa-minus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Pour prendre rendez vous\/Urgence :<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2091\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-2091\"><ul><li><p><span style=\"font-size: 14pt\"><strong>Service d\u2019H\u00e9matologie H\u00f4pital Trousseau<br \/>Jours ouvrables<\/strong> : <span style=\"color: #ed1164\"><strong>02 47 47 46 15<\/strong><\/span> ou <span style=\"color: #ed1164\"><strong>02 47 47 46 72<br \/><\/strong><\/span><strong>Week-end\/Nuits\/F\u00e9ri\u00e9s<\/strong> : <span style=\"color: #ed1164\"><strong>02 47 47 81 20<\/strong><\/span><\/span><\/p><\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1366e3c3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1366e3c3\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2cd27e47\" data-id=\"2cd27e47\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1bfcbc52 elementor-widget elementor-widget-image\" data-id=\"1bfcbc52\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"62\" src=\"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-content\/uploads\/sites\/15\/2023\/02\/recherche-trans-300x62-1.png\" class=\"attachment-medium size-medium wp-image-386\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">PROTOCOLES EN COURS<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-535eb333 elementor-widget elementor-widget-toggle\" data-id=\"535eb333\" data-element_type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1391\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1391\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\"><span style=\"text-transform: uppercase\"><strong>Protocoles en cours<\/strong><\/span><\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1391\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1391\"><p><strong>Protocoles en cours :<\/strong><\/p><ol><li><p><strong>Gena 22<\/strong> : Nuwiq pour les soins p\u00e9riop\u00e9ratoires Prise en charge des patients atteints d&#8217;h\u00e9mophilie A dans le cadre de l&#8217;\u00e9tude sur la prophylaxie r\u00e9guli\u00e8re par l&#8217;Emicizumab.<\/p><p>\u00a0<\/p><\/li><li><p><strong>Gena 23<\/strong> : Etude sur la prise en charge des femmes\/filles atteintes d&#8217;h\u00e9mophilie A n\u00e9cessitant un traitement au FVIII en vue d&#8217;une intervention chirurgicale \u00e9tude internationale, ouverte et non contr\u00f4l\u00e9e (NuDIMENSION).<\/p><\/li><li><p><strong>OrPHEe<\/strong> : Observatoire des patients pr\u00e9sentant une H\u00e9mophilie B trait\u00e9s par Idelvion<\/p><\/li><li><p><strong>SANTESEX-HEMO<\/strong> : Evaluation de la sant\u00e9 sexuelle chez les patients atteints de maladies h\u00e9morragiques<\/p><\/li><li><p><strong>Seniorhemo<\/strong> : Etat de sant\u00e9 objectif et per\u00e7u des seniors atteints d\u2019h\u00e9mophilie mod\u00e9r\u00e9e ou s\u00e9v\u00e8re en France<\/p><\/li><\/ol><p>Le Centre de Tours est partenaire du R\u00e9seau <strong>FranceCoag<\/strong> (RFC). RFC est une base de donn\u00e9es fran\u00e7aises anonyme de recherche et de veille sanitaire dans le domaine des maladies h\u00e9morragiques (h\u00e9mophilies, maladies de Willebrand, d\u00e9ficits rares en facteur de coagulation et pathologies plaquettaires).<\/p><p>&gt;\u00a0<a href=\"https:\/\/www.francecoag.org\/SiteWebPublic\/html\/accueil.html\" target=\"_blank\" rel=\"noopener\">https:\/\/www.francecoag.org\/SiteWebPublic\/html\/accueil.html<\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5e5c0b9c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5e5c0b9c\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7203258f\" data-id=\"7203258f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-289ae3c2 elementor-view-stacked elementor-shape-circle elementor-widget elementor-widget-icon\" data-id=\"289ae3c2\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<i aria-hidden=\"true\" class=\"fas fa-book-reader\"><\/i>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-31f531af elementor-widget elementor-widget-toggle\" data-id=\"31f531af\" data-element_type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-8381\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-8381\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\"><span style=\"text-transform: uppercase\"><strong>PUBLICATIONS 2019-2022<\/strong><\/span><\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-8381\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-8381\"><h4>2023<\/h4><p>Alessi MC, Coxon C, Ibrahim-Kosta M, Bacci M, Voisin S, Rivera J, Greinacher A, Raster J, Pulcinelli F, Devreese KMJ, Mullier F, McCormick AN, Frontroth JP, <span style=\"color: #ed1164;\"><strong>Pouplard C<\/strong><\/span>, Sachs UJ, Diaz I, Bermejo N, Camera M, Fontana P, Bauters A,Stepanian A, Cozzi MR, Sveshnikova AN, Faille D, Hollon W, Chitlur M, Casonato A, Lasne D, Lavenu-Bombled C, Fiore M, Hamidou B, Hurtaud-Roux MF, Saultier P, Goumidi L, Gresele P, Lordkipanidz\u00e9 M. Multicenter evaluation of light transmission platelet aggregation reagents: communication from the ISTH SSC Subcommittee on Platelet Physiology. J Thromb Haemost. 2023 Sep;21(9):2596-2610<\/p><p>Guillet B, Hassoun A, Wibaut B, Harroche A, Biron-Andr\u00e9ani C, Repesse Y, d&#8217;Oiron R, Tardy B, Pan Petesch B, Chamouni P, Gay V, Fouassier M, <span style=\"color: #ed1164;\"><strong>Pouplard C<\/strong><\/span>, Martin C, Catovic H, Delavenne X. A French Real-World Evidence Study Evaluating the Efficacy, Safety, and Pharmacokinetic Parameters of rVIII-SingleChain in Patients with Hemophilia A Receiving Prophylaxis. Thromb Haemost. 2023 May;123(5):490-500.<\/p><h4>2022<\/h4><ul><li><strong>rFVIII-Fc in severe haemophilia A: The incentive switch in case of high risk of joint bleedings<\/strong>. Val\u00e9rie Horvais,\u00a0Matthieu Wargny,\u00a0Yohann Repess\u00e9, Beno\u00eet Guillet,\u00a0Philippe Beurrier,\u00a0<span style=\"color: #ed1164;\"><strong>Laurent Ardillon<\/strong><\/span>,\u00a0Brigitte Pan-Petesch,\u00a0Vincent Cussac,\u00a0Marc Trossa\u00ebrt. 2022 Oct;52(10):e13824. doi: 10.1111\/eci.13824. Epub 2022 Jun 27.<\/li><li>Ternisien C, Lasne D, Grand F, Harzallah I, Jeanpierre E, Repesse Y, Ryman A, Sapin AF, Voisin S, Nougier C, <strong><span style=\"color: #ed1164;\">Pouplard C<\/span><\/strong>; French study group on laboratory management of bleeding disorders (BIMHO Group-GFHT). Impact of aPTT reagents on measurement of a PEGylated recombinant FVIII (Adynovi\u00ae\/Adynovate\u00ae): A French multicentric field assay study. Int J Lab Hematol. 2022 Apr;44(2):e55-e59.<\/li><li>Tardy B, Lambert T, Chamouni P, Montmartin A, Trossaert M, Claeyssens S, Berger C, <strong><span style=\"color: #ed1164;\">Ardillon L<\/span><\/strong>, Gay V, Delavenne X, Harroche A, Chelle P. Revised terminal half-life of nonacog alfa as derived from extended sampling data: A real-world study involving 64 haemophilia B patients on nonacog alfa regular prophylaxis. Haemophilia. 2022 Jul;28(4):542-547. doi: 10.1111\/hae.14560. Epub 2022 Apr 14<\/li><\/ul><h4>2021<\/h4><p>Baglo T, <strong>Pouplard C<\/strong>, Valentin JB, Gu\u00e9ry EA, Gruel Y, Vayne C. Acquired platelet defect associated with gabapentin treatment: a case-report. Platelets. 2021 Aug 18;32(6):846-849.<\/p><p>Sanni\u00e9 T, de Moerloose P; AFATH. How to implement medical and patient associations in low-income countries: A proposition from the African French Alliance for the Treatment of Haemophilia (AFATH). Haemophilia. 2021 Mar;27(2):261-269.<strong> (Auteur associ\u00e9)<\/strong><\/p><h4>2020<\/h4><ul><li><strong>Bleeding complications during pregnancy and delivery in haemophilia carriers and their neonates in Western France: An observational study<\/strong>. Nau A, Gillet B, Guillet B, Beurrier P,\u00a0<span style=\"color: #ed1164;\"><strong>Ardillon L<\/strong><\/span>, Cussac V, Guillou S, Raj L, Trossa\u00ebrt M, Horvais V, Bayart S, Potin J, Rose J, Macchi L, Couturaud F, Lacut K, Pan-Petesch B.Haemophilia. 2020 Nov;26(6):1046-1055. doi: 10.1111\/hae.14117. Epub 2020 Aug 25.PMID:\u00a032842170\u00a0<\/li><li><strong>Evaluation of functional assays for the diagnosis of heparin induced thrombocytopenia using 5B9, a monoclonal IgG that mimics human antibodies<\/strong>. Vayne C, Gu\u00e9ry EA, Charuel N, Besombes J, Lambert WC, Rollin J, Gruel Y, <span style=\"color: #ed1164;\"><strong>Pouplard C<\/strong><\/span>. J Thromb Haemost. 2020 Jan 29.<\/li><li><strong>[Therapeutic antibodies in hemostasis. From the past to the future]<\/strong>. <span style=\"color: #ed1164;\"><strong>Gruel Y<\/strong><\/span>, Kizlik-Masson C, Lenting P. Med Sci (Paris). 2019 Dec Epub 2020 Jan 6<\/li><li><p>Nougier C, Jeanpierre E, Ternisien C, Proulle V, Hezard N, <span style=\"color: #ed1164;\"><b>Pouplard<\/b><b> C<\/b><\/span>, Lasne D; With contributions from the Working Group on Biology of Haemorrhagic Disorders (BIMHO, Under the Aegis of GFHT). Emicizumab treatment: Impact on coagulation tests and biological monitoring of haemostasis according to clinical situations (BIMHO group proposals). Eur J Haematol. 2020 Dec;105(6):675-681.<\/p><p>\u00a0<\/p><\/li><li><p>Jeanpierre E, <span style=\"color: #ed1164;\"><b>Pouplard<\/b><b> C<\/b><\/span>, Lasne D, Le Cam Duchez V, Eschwege V, Flaujac C, Galinat H, Harzallah I, Proulle V, Smahi M, Sobas F, Stepina N, Toulon P, Voisin S, Ternisien C, Nougier C; French Study Group on the Biology of Hemorrhagic Diseases (the BIMHO group). Factor VIII and IX assays for post-infusion monitoring in hemophilia patients: Guidelines from the French BIMHO group (GFHT). Eur J Haematol. 2020 Aug;105(2):103-115.<\/p><p>\u00a0<\/p><\/li><li><p>Allard Q, Djerada Z, <span style=\"color: #ed1164;\"><b>Pouplard<\/b><b> C<\/b><\/span>, Repess\u00e9 Y, Desprez D, Galinat H, Frotscher B, Berger C, Harroche A, Ryman A, Flaujac C, Chamouni P, Guillet B, Volot F, Szymezak J, Nguyen P, Cazaubon Y. Real Life Population Pharmacokinetics Modelling of Eight Factors VIII in Patients with Severe Haemophilia A: Is It Always Relevant to Switch to an Extended Half-Life? Pharmaceutics. 2020 Apr 21;12(4):380.<\/p><p>\u00a0<\/p><\/li><li><p><span style=\"color: #ed1164;\"><b>Pouplard<\/b><b> C<\/b><\/span>, Sattler L, Ryman A, Eschwege V, De Maistre E, Flaujac C, Szymezak J, Grand F, Repesse Y, Galinat H, Donnard M, Ternisien C, Iorio A, Chelle P, Jeanpierre E; \u2018Biology Study Group on Haemorrhagic Diseases\u2019 (Group BIMHO &#8211; GFHT). Multicentre pharmacokinetic evaluation of rFVIII-Fc (efmoroctocog alfa) in a real life and comparison with non-extended half-life FVIII concentrates. Haemophilia. 2020 Mar;26(2):282-289.<\/p><p>\u00a0<\/p><\/li><li><p>Nau A, Gillet B, Guillet B, Beurrier P,<b><span style=\"color: #ed1164;\"> Ardillon L<\/span>, <\/b>Cussac V, Guillou S, Raj L, Trossa\u00ebrt M, Horvais V, Bayart S, Potin J, Rose J, Macchi L, Couturaud F, Lacut K, Pan-Petesch B. Bleeding complications during pregnancy and delivery in haemophilia carriers and their neonates in Western France: An observational study. Haemophilia. 2020 Nov;26(6):1046-1055.<\/p><\/li><\/ul><h4>2019<\/h4><ul><li><p><strong>Use of von Willebrand Factor Concentrate in Inherited von Willebrand Disease: How Often Is It Useful to Add Factor VIII? <\/strong>Drillaud N, <strong><span style=\"color: #ed1164;\">Ardillon L<\/span><\/strong>, Ternisien C, <span style=\"color: #ed1164;\"><strong>Valentin JB<\/strong><\/span>, Fouassier M, Gillet B, <span style=\"color: #ed1164;\"><strong>Gruel Y<\/strong><\/span>, Sigaud M, Horvais V, Bene MC, Trossa\u00ebrt M. Transfus Med Rev. 2019 Nov 1<\/p><\/li><li><p><strong>Management of bleeding and invasive procedures in haemophilia A patients with inhibitor treated with emicizumab (Hemlibra\u00ae ): Proposals from the French network on inherited bleeding disorders (MHEMO), the French Reference Centre on Haemophilia, in collaboration with the French Working Group on Perioperative Haemostasis (GIHP)<\/strong>. Susen S, <span style=\"color: #ed1164;\"><strong>Gruel Y<\/strong><\/span>, Godier A, Harroche A, Chambost H, Lasne D, Rauch A, Roullet S, Fontana P, Goudemand J, de Maistre E, Chamouard V, Wibaut B, Albaladejo P, N\u00e9grier C. Haemophilia. 2019 Sep<\/p><\/li><li><p><strong>Multicentre evaluation of CK Prest\u00ae for assaying plasma levels of factor IX fused with albumin (Idelvion\u00ae )<\/strong>. <span style=\"color: #ed1164;\"><strong>Pouplard C<\/strong><\/span>, Galinat H, Ternisien C, Blanc Jouvan F, De Maistre E, Duchemin J, Flaujac C, H\u00e9zard N, Grand F, Le Cam-Duchez V, Marlu R, Mourey G, Nedelec F, Pineau-Vincent F, Repesse Y, St\u00e9panian A, Szymezak J, Voisin S, Voyer AL, Jeanpierre E, Lasne D; French Study Group on Laboratory Management of bleeding disorders (BIMHO group). Haemophilia. 2019 Sep<\/p><\/li><li><p><strong>Estimation of Nuwiq\u00ae (simoctocog alfa) activity using one-stage and chromogenic assays-Results from an international comparative field study<\/strong>. Tiefenbacher S, Albisetti M, Baker P, Kappert G, Kitchen S, Kremer Hovinga JA, <span style=\"color: #ed1164;\"><strong>Pouplard C<\/strong><\/span>, Scholz U, Ternisien C, Borgvall C, Vicente T, Belyanskaya L, Walter O, Oldenburg J; Nuwiq Field Study Participating Laboratories. Haemophilia. 2019 Jul<\/p><\/li><li><p><strong>Frequency and Clinical Impact of Platelet Factor 4-Specific Antibodies in Patients Undergoing Extracorporeal Membrane Oxygenation<\/strong>. Vayne C, May MA, Bourguignon T, Lemoine E, Guery EA, Rollin J, <span style=\"color: #ed1164;\"><strong>Gruel Y<\/strong><\/span>, <span style=\"color: #ed1164;\"><strong>Pouplard C<\/strong><\/span>. Thromb Haemost. 2019 Jul<\/p><\/li><li><strong>Using pharmacokinetics for tailoring prophylaxis in people with hemophilia switching between clotting factor products: A scoping review<\/strong>. Yu JK, Iorio A, Edginton AN; WAPPS co\u2010investigators. Collaborateur: <span style=\"color: #ed1164;\"><strong>Pr. Y. GRUEL<\/strong><\/span> Res Pract Thromb Haemost. 2019 May 20<\/li><li><strong>Cleavage of anti-PF4\/heparin IgG by a bacterial protease and potential benefit in heparin-induced thrombocytopenia<\/strong>. Kizlik-Masson C, Deveuve Q, Zhou Y, Vayne C, Thibault G, McKenzie SE, <span style=\"color: #ed1164;\"><strong>Pouplard C<\/strong><\/span>, Loyau S, <span style=\"color: #ed1164;\"><strong>Gruel Y<\/strong><\/span>, Rollin J. Blood. 2019 May 30<\/li><li><strong>Bleeding risk for patients with haemophilia under antithrombotic therapy. Results of the French multicentric study ERHEA<\/strong>.Desjonqueres A, Guillet B, Beurrier P, Pan-Petesch B, <span style=\"color: #ed1164;\"><strong>Ardillon L<\/strong><\/span>, Pineau-Vincent F, Sigaud M, Fouassier M, Ternisien C, Gillet B, B\u00e9n\u00e9 MC, Horvais V, Lienhart A, Trossa\u00ebrt M. Br J Haematol. 2019 May;<\/li><li><strong>Etiology and Outcomes of Thrombotic Microangiopathies<\/strong>. Bayer G, von Tokarski F, Thoreau B, Bauvois A, Barbet C, Cloarec S, M\u00e9rieau E, Lachot S, Garot D, Bernard L, Gyan E, Perrotin F, <span style=\"color: #ed1164;\"><strong>Pouplard C<\/strong><\/span>, Maillot F, Gatault P, Sautenet B, Rusch E, Buchler M, Vigneau C, Fakhouri F, Halimi JM. Clin J Am Soc Nephrol. 2019 Apr<\/li><li><strong>Fibronectin: a &#8220;double hit&#8221; modulator in HIT?<\/strong> <span style=\"color: #ed1164;\"><strong>Gruel Y<\/strong><\/span>, Rollin J. Blood. 2019 Feb 28<\/li><li><strong>Management of antiplatelet therapy for non-elective invasive procedures or bleeding complications: Proposals from the French Working Group on Perioperative Haemostasis (GIHP) and the French Study Group on Thrombosis and Haemostasis (GFHT), in collaboration with the French Society for Anaesthesia and Intensive Care (SFAR)<\/strong>. Godier A, Garrigue D, Lasne D, Fontana P, Bonhomme F, Collet JP, de Maistre E, Ickx B, <span style=\"color: #ed1164;\"><strong>Gruel Y<\/strong><\/span>, Mazighi M, Nguyen P, Vincentelli A, Albaladejo P, Lecompte T; French Working Group on Perioperative Haemostasis (GIHP). Arch Cardiovasc Dis. 2019 Mar<\/li><li><strong>Factor VIII assays in treated hemophilia A patients<\/strong>. Lasne D, <span style=\"color: #ed1164;\"><strong>Pouplard C<\/strong><\/span>, Nougier C, Eschwege V, Le Cam Duchez V, Proulle V, Smahi M, Harzallah I, Voisin S, Toulon P, Sobas F, Galinat H, Flaujac C, Ternisien C, Jeanpierre E; groupe d&#8217;\u00e9tudes de la biologie des maladies h\u00e9morragiques du Groupe fran\u00e7ais d&#8217;\u00e9tudes de l&#8217;h\u00e9mostase et la thrombose. Ann Biol Clin (Paris). 2019 Feb<\/li><li><strong>Factor IX assays in treated hemophilia B patients<\/strong>. <span style=\"color: #ed1164;\"><strong>Pouplard C<\/strong><\/span>, Jeanpierre E, Lasne D, Le Cam Duchez V, Eschwege V, Flaujac C, Galinat H, Harzallah I, Proulle V, Smahi M, Sobas F, Ternisien C, Toulon P, Voisin S, Nougier C; groupe d\u2019\u00e9tudes de la biologie des maladies h\u00e9morragiques du Groupe fran\u00e7ais d\u2019\u00e9tudes de l\u2019h\u00e9mostase et la thrombose. Ann Biol Clin (Paris). 2019 Feb<\/li><\/ul><p><\/p><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section><\/div> <a href=\"https:\/\/www.chu-tours.fr\/pemr-cvl\/maladies-hemorragiques-constitutionnelles\/#more-380\" class=\"more-link elementor-more-link\"><span aria-label=\"Poursuivre la lecture Maladies H\u00e9morragiques Constitutionnelles\">(plus\u2026)<\/span><\/a>","protected":false},"excerpt":{"rendered":"<p>Centre de Ressources et de Comp\u00e9tences Maladies H\u00e9morragiques Constitutionnelles Le Centre de r\u00e9f\u00e9rence constitutif est compos\u00e9 d\u2019une \u00e9quipe multidisciplinaire sp\u00e9cialis\u00e9e dans la prise en charge des Maladies H\u00e9morragiques Constitutionnelles. Ses missions : Faciliter le diagnostic et la prise en charge des patients Coordonner et participer \u00e0 des travaux de recherche (fondamentales, cliniques, \u00e9pid\u00e9miologiques) Am\u00e9liorer la [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"publishpress_future_action":{"enabled":false,"date":"2025-06-15 06:11:43","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"_links":{"self":[{"href":"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-json\/wp\/v2\/pages\/380"}],"collection":[{"href":"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-json\/wp\/v2\/comments?post=380"}],"version-history":[{"count":16,"href":"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-json\/wp\/v2\/pages\/380\/revisions"}],"predecessor-version":[{"id":2259,"href":"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-json\/wp\/v2\/pages\/380\/revisions\/2259"}],"wp:attachment":[{"href":"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-json\/wp\/v2\/media?parent=380"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}