{"id":2334,"date":"2024-06-04T11:19:27","date_gmt":"2024-06-04T09:19:27","guid":{"rendered":"https:\/\/www.chu-tours.fr\/pemr-cvl\/?page_id=2334"},"modified":"2024-06-04T11:27:22","modified_gmt":"2024-06-04T09:27:22","slug":"centre-de-reference-constitutif-des-microangiopathies-thrombotiques-mat","status":"publish","type":"page","link":"https:\/\/www.chu-tours.fr\/pemr-cvl\/centre-de-reference-constitutif-des-microangiopathies-thrombotiques-mat\/","title":{"rendered":"Centre de R\u00e9f\u00e9rence Constitutif des MicroAngiopathies Thrombotiques (MAT)"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"2334\" class=\"elementor elementor-2334\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-69e0228d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"69e0228d\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-23cb63ad\" data-id=\"23cb63ad\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-2197be85 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2197be85\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-4ab65f4e\" data-id=\"4ab65f4e\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4977fa4 elementor-widget elementor-widget-image\" data-id=\"4977fa4\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 15-07-2024 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"131\" height=\"101\" src=\"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-content\/uploads\/sites\/15\/2023\/02\/logo-crmr.png\" class=\"attachment-large size-large wp-image-361\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-4d856882\" data-id=\"4d856882\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-6ab89bd6\" data-id=\"6ab89bd6\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3677b6a4 elementor-widget elementor-widget-image\" data-id=\"3677b6a4\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"230\" height=\"109\" src=\"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-content\/uploads\/sites\/15\/2024\/06\/logo-MaRIH.png\" class=\"attachment-large size-large wp-image-2336\" alt=\"Logo MaRIH\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6bfa0b8c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6bfa0b8c\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3c213175\" data-id=\"3c213175\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2708ec89 elementor-widget elementor-widget-text-editor\" data-id=\"2708ec89\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 15-07-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p><b>Le Centre de r\u00e9f\u00e9rence constitutif est compos\u00e9 d\u2019une \u00e9quipe pluridisciplinaire sp\u00e9cialis\u00e9e dans la prise en charge des <\/b><b>MicroAngiopathies<\/b><b> Thrombotiques (MAT). <\/b><\/p><p><b>Ses missions :<\/b><\/p><ul><li>Assurer le diagnostic et la coordination des soins pour les patients (enfants et adultes) atteints de microangiopathies thrombotiques<\/li><li>Coordonner et participer \u00e0 des projets de recherche (fondamentales, cliniques, \u00e9pid\u00e9miologiques)<\/li><li>Promouvoir l\u2019enseignement et la formation<\/li><\/ul><p><b>Le centre est membre de la Fili\u00e8re de Sant\u00e9 Maladies Rares <\/b><b>MaRIH<\/b><b> (Maladies Rares <\/b><b>Immuno-H\u00e9matologiques<\/b><b>)<\/b><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-2de84742 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2de84742\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-291c6b30\" data-id=\"291c6b30\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-64faffec elementor-widget elementor-widget-image\" data-id=\"64faffec\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"40\" height=\"40\" src=\"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-content\/uploads\/sites\/15\/2023\/02\/uk-flag-square-icon-128-40x40-1-40x40.png\" class=\"attachment-pictogramme-home size-pictogramme-home wp-image-372\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-2fd52d09\" data-id=\"2fd52d09\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-70c42876 elementor-widget elementor-widget-toggle\" data-id=\"70c42876\" data-element_type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 15-07-2024 *\/\n.elementor-toggle{text-align:start}.elementor-toggle .elementor-tab-title{font-weight:700;line-height:1;margin:0;padding:15px;border-bottom:1px solid #d5d8dc;cursor:pointer;outline:none}.elementor-toggle .elementor-tab-title .elementor-toggle-icon{display:inline-block;width:1em}.elementor-toggle .elementor-tab-title .elementor-toggle-icon svg{margin-inline-start:-5px;width:1em;height:1em}.elementor-toggle .elementor-tab-title .elementor-toggle-icon.elementor-toggle-icon-right{float:right;text-align:right}.elementor-toggle .elementor-tab-title .elementor-toggle-icon.elementor-toggle-icon-left{float:left;text-align:left}.elementor-toggle .elementor-tab-title .elementor-toggle-icon .elementor-toggle-icon-closed{display:block}.elementor-toggle .elementor-tab-title .elementor-toggle-icon .elementor-toggle-icon-opened{display:none}.elementor-toggle .elementor-tab-title.elementor-active{border-bottom:none}.elementor-toggle .elementor-tab-title.elementor-active .elementor-toggle-icon-closed{display:none}.elementor-toggle .elementor-tab-title.elementor-active .elementor-toggle-icon-opened{display:block}.elementor-toggle .elementor-tab-content{padding:15px;border-bottom:1px solid #d5d8dc;display:none}@media (max-width:767px){.elementor-toggle .elementor-tab-title{padding:12px}.elementor-toggle .elementor-tab-content{padding:12px 10px}}.e-con-inner>.elementor-widget-toggle,.e-con>.elementor-widget-toggle{width:var(--container-widget-width);--flex-grow:var(--container-widget-flex-grow)}<\/style>\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1891\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1891\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\"><em>The reference centre is composed of a multidisciplinary team specialised in the care of Thrombotic microangiopathies. <\/em><\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1891\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1891\"><p><em><strong>The duties of the centre are :<\/strong><\/em><\/p><ul><li>Ensure the diagnostic and the coordination of care for pediatric and adult patients with thrombotic microangiopathies<\/li><li>Organise and participate in research projects (fundamental, clinical, epidemiological)<\/li><li>Promote education and training<\/li><\/ul><p><b>The centre <\/b><b>is<\/b><b> a <\/b><b>member<\/b><b> of the French National Rare <\/b><b>Disease<\/b><b> Network <\/b><b>MaRIH<\/b><b> (<\/b><b>Rare <\/b><b>Immunohematological<\/b><b> Diseases)<\/b><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2e0916bc elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2e0916bc\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3a094600\" data-id=\"3a094600\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-677b6b37 elementor-widget elementor-widget-image\" data-id=\"677b6b37\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"226\" src=\"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-content\/uploads\/sites\/15\/2024\/06\/microangiopathies-thrombotiques-300x226.png\" class=\"attachment-medium size-medium wp-image-2340\" alt=\"\" srcset=\"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-content\/uploads\/sites\/15\/2024\/06\/microangiopathies-thrombotiques-300x226.png 300w, https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-content\/uploads\/sites\/15\/2024\/06\/microangiopathies-thrombotiques-70x52.png 70w, https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-content\/uploads\/sites\/15\/2024\/06\/microangiopathies-thrombotiques.png 352w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Microangiopathies Thrombotiques <\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-73aa098a elementor-widget elementor-widget-toggle\" data-id=\"73aa098a\" data-element_type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1941\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1941\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\"><span style=\"text-transform: uppercase\"><strong>Pathologies concern\u00e9es<\/strong><\/span><\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1941\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1941\"><p><b>QU&#8217;EST-CE QU\u2019UNE MICROANGIOPATHIE THROMBOTIQUE ?<\/b><\/p><p>Les <b>Microangiopathies Thrombotiques (MAT) <\/b>sont des pathologies caract\u00e9ris\u00e9es par des l\u00e9sions au niveau des vaisseaux sanguins <b>(microangiopathies) <\/b>dues \u00e0 la formation de caillots sanguins <b>(thrombose). <\/b>Elles posent de nombreux probl\u00e8mes de diagnostic et de prise en charge car leurs manifestations cliniques et biologiques initiales sont trompeuses. On distingue :<\/p><ul><li><b>Le syndrome h\u00e9molytique et ur\u00e9mique <\/b>(SHU), pour lequel les atteintes sont essentiellement r\u00e9nales.<\/li><li><b>Le<\/b> <b>purpura thrombotique <\/b><b>thrombocytop\u00e9nique<\/b> (PTT), pour lequel les atteintes sont essentiellement neurologiques et cardiaques.<\/li><li><b>Les MAT qui sont secondaires <\/b>au cancer, chimioth\u00e9rapie, allogreffes de cellules souches h\u00e9matopo\u00ef\u00e9tiques, VIH, grossesse\u2026<\/li><\/ul><p><b>COMBIEN DE PERSONNES SONT ATTEINTES DE CETTE MALADIE ?<\/b><\/p><p>\u00a0La MAT est une maladie rare, ce qui signifie qu&#8217;elle affecte g\u00e9n\u00e9ralement un petit pourcentage de la population.<\/p><p>Environ 2 cas sur 1 million d&#8217;habitants sont signal\u00e9s chaque ann\u00e9e.<\/p><p><b>A QUOI EST-ELLE DUE ET COMMENT LA PRENDRE EN CHARGE ? <\/b><\/p><p>La MAT est une maladie complexe dont les m\u00e9canismes ne sont pas toujours compris. Les facteurs peuvent \u00eatre g\u00e9n\u00e9tiques, m\u00e9dicamenteux, infectieux ou encore li\u00e9s \u00e0 des conditions m\u00e9dicales particuli\u00e8res telles que la grossesse, le lupus \u00e9ryth\u00e9mateux syst\u00e9mique, la scl\u00e9rodermie syst\u00e9mique ou encore d\u2019autres maladies auto-immunes.<\/p><p>La prise en charge de la MAT implique souvent une approche multidisciplinaire, comprenant des traitements visant \u00e0 pr\u00e9venir la formation de caillots sanguins, \u00e0 traiter les complications et \u00e0 g\u00e9rer les sympt\u00f4mes.<\/p><p><span style=\"color: #2bb718;\"><strong>&gt;&gt; Plus d\u2019informations sur les maladies rares :<\/strong><\/span> <a href=\"http:\/\/www.orphanet.fr\/\" target=\"_blank\" rel=\"noopener\">www.orphanet.fr<\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5cba2da8 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5cba2da8\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2223d3b5\" data-id=\"2223d3b5\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4150c4b8 elementor-widget elementor-widget-image\" data-id=\"4150c4b8\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"200\" src=\"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-content\/uploads\/sites\/15\/2024\/06\/equipe-foie-300x200.jpg\" class=\"attachment-medium size-medium wp-image-2308\" alt=\"\" srcset=\"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-content\/uploads\/sites\/15\/2024\/06\/equipe-foie-300x200.jpg 300w, https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-content\/uploads\/sites\/15\/2024\/06\/equipe-foie-1024x683.jpg 1024w, https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-content\/uploads\/sites\/15\/2024\/06\/equipe-foie-768x512.jpg 768w, https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-content\/uploads\/sites\/15\/2024\/06\/equipe-foie.jpg 1080w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">L'\u00c9QUIPE<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-5a351ce elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5a351ce\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-e7587a2\" data-id=\"e7587a2\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3883e69f elementor-widget elementor-widget-toggle\" data-id=\"3883e69f\" data-element_type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-9481\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-9481\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\"><span style=\"text-transform: uppercase\"><strong>L'\u00e9quipe m\u00e9dicale<\/strong><\/span><\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-9481\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-9481\"><p><b>M\u00e9decin coordonnateur :<\/b><\/p><ul><li>Pr Jean-Michel HALIMI &#8211; N\u00e9phrologue<\/li><\/ul><p><b>L\u2019\u00e9quipe :<\/b><\/p><ul><li>Pr Matthias B\u00dcCHLER &#8211; N\u00e9phrologue<\/li><li>Dr Christelle BARBET &#8211; N\u00e9phrologue<\/li><li>Dr B\u00e9n\u00e9dicte SAUTENET &#8211; N\u00e9phrologue<\/li><li>Dr H\u00e9l\u00e8ne LONGUET &#8211; N\u00e9phrologue<\/li><li>Pr Philippe GATAULT &#8211; N\u00e9phrologue<\/li><li>Dr Valentin MAISONS &#8211; N\u00e9phrologue<\/li><li>Dr Alexandre FILLON &#8211; N\u00e9phrologue<\/li><li>Dr Paul DELALANDE &#8211; N\u00e9phrologue<\/li><li>Dr Elodie MERIEAU &#8211; N\u00e9phrologue P\u00e9diatrique<\/li><li>Dr Sylvie CLOAREC &#8211; N\u00e9phrologue P\u00e9diatrique<\/li><li>Dr Violaine LEFRANC &#8211; N\u00e9phrologue P\u00e9diatrique<\/li><li>Dr Yannis CHARTIER &#8211; N\u00e9phrologue P\u00e9diatrique<\/li><li>Dr Adrien BIGOT \u2013 M\u00e9decin interniste<\/li><li>Pr Fran\u00e7ois MAILLOT \u2013 M\u00e9decin interniste<\/li><li>Dr Denis GAROT \u2013 M\u00e9decin r\u00e9animateur<\/li><li>Dr Charlotte SALMON \u2013 M\u00e9decin r\u00e9animateur<\/li><li>Dr Adrien LEMAIGNEN &#8211; Maladies infectieuses<\/li><li>Pr Franck PERROTIN \u2013 Gyn\u00e9cologue obst\u00e9tricien<\/li><li>Dr Carine ARLICOT \u2013 Gyn\u00e9cologue obst\u00e9tricien<\/li><li>Pr Emmanuel GYAN &#8211; Oncologie\/H\u00e9matologie<\/li><li>Dr Alban VILLATE &#8211; Oncologie\/H\u00e9matologie<\/li><li>Mme Nadine BAROUKH, PhD &#8211; Ing\u00e9nieure de recherche<\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-61b006b\" data-id=\"61b006b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6837ac8 elementor-widget elementor-widget-toggle\" data-id=\"6837ac8\" data-element_type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1091\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1091\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\"><span style=\"text-transform: uppercase\"><strong>L'\u00c9quipe param\u00e9dicale<\/strong><\/span><\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1091\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1091\"><ul><li>Mme Claire DROUAULT \u2013 Infirmi\u00e8re de recherche clinique<\/li><li>M. Olivier BOURGAULT \u2013 Infirmier de recherche clinique<\/li><li>Mme Chantal RAIMBAULT \u2013 Psychologue<\/li><li>Mme Aur\u00e9lie PROUX \u2013 Assistante Sociale<\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-96d2d43 elementor-widget elementor-widget-toggle\" data-id=\"96d2d43\" data-element_type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1581\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1581\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\"><span style=\"text-transform: uppercase\"><strong>laboratoire de diagnostic<\/strong><\/span><\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1581\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1581\"><ul><li>Pr Claire POUPLARD \u2013 Service d\u2019H\u00e9matologie \u2013 H\u00e9mostase (labellis\u00e9 LBMR)<\/li><li>Dr Caroline VAYNE\u2013 Service d\u2019H\u00e9matologie \u2013 H\u00e9mostase (labellis\u00e9 LBMR)<\/li><li>M. J\u00e9r\u00f4me ROLLIN\u2013 Service d\u2019H\u00e9matologie \u2013 H\u00e9mostase (labellis\u00e9 LBMR)<\/li><li>Pr Gilles PAINTAUD \u2013 Laboratoire de Pharmacologie et Toxicologie<\/li><li>Dr David TERNANT \u2013 Pharmacologie m\u00e9dicale<\/li><li>Dr Olivier LE TILLY &#8211; Pharmacologie m\u00e9dicale<\/li><li>Dr Eric PIVER \u2013 Laboratoire de Biochimie<\/li><li>Dr M\u00e9d\u00e9ric JEANNE &#8211; G\u00e9n\u00e9ticien<\/li><li>Dr St\u00e9phanie ARPIN &#8211; G\u00e9n\u00e9ticienne<\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6b4ff18 elementor-widget elementor-widget-toggle\" data-id=\"6b4ff18\" data-element_type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1121\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1121\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\"><span style=\"text-transform: uppercase\"><strong>Inserm UMR 1327 ISCHEMIA<\/strong><\/span><\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1121\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1121\"><ul><li>Pr S\u00e9bastien ROGER<\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-64323447 elementor-widget elementor-widget-accordion\" data-id=\"64323447\" data-element_type=\"widget\" data-widget_type=\"accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 15-07-2024 *\/\n.elementor-accordion{text-align:start}.elementor-accordion .elementor-accordion-item{border:1px solid #d5d8dc}.elementor-accordion .elementor-accordion-item+.elementor-accordion-item{border-top:none}.elementor-accordion .elementor-tab-title{margin:0;padding:15px 20px;font-weight:700;line-height:1;cursor:pointer;outline:none}.elementor-accordion .elementor-tab-title .elementor-accordion-icon{display:inline-block;width:1.5em}.elementor-accordion .elementor-tab-title .elementor-accordion-icon svg{width:1em;height:1em}.elementor-accordion .elementor-tab-title .elementor-accordion-icon.elementor-accordion-icon-right{float:right;text-align:right}.elementor-accordion .elementor-tab-title .elementor-accordion-icon.elementor-accordion-icon-left{float:left;text-align:left}.elementor-accordion .elementor-tab-title .elementor-accordion-icon .elementor-accordion-icon-closed{display:block}.elementor-accordion .elementor-tab-title .elementor-accordion-icon .elementor-accordion-icon-opened,.elementor-accordion .elementor-tab-title.elementor-active .elementor-accordion-icon-closed{display:none}.elementor-accordion .elementor-tab-title.elementor-active .elementor-accordion-icon-opened{display:block}.elementor-accordion .elementor-tab-content{display:none;padding:15px 20px;border-top:1px solid #d5d8dc}@media (max-width:767px){.elementor-accordion .elementor-tab-title{padding:12px 15px}.elementor-accordion .elementor-tab-title .elementor-accordion-icon{width:1.2em}.elementor-accordion .elementor-tab-content{padding:7px 15px}}.e-con-inner>.elementor-widget-accordion,.e-con>.elementor-widget-accordion{width:var(--container-widget-width);--flex-grow:var(--container-widget-flex-grow)}<\/style>\t\t<div class=\"elementor-accordion\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1681\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1681\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><i class=\"fas fa-plus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><i class=\"fas fa-minus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Pour prendre rendez vous :<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1681\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1681\"><h4>Pour prendre rendez-vous :<\/h4><p><strong><span style=\"color: #ed1164;\">Adulte<\/span> <\/strong><br \/><strong>H\u00f4pital Bretonneau (B\u00e2timent B2A)<\/strong><\/p><ul><li>T\u00e9l : <span style=\"color: #ed1164; font-size: 14pt;\"><strong>02 47 47 37 46<br \/><\/strong><span style=\"font-size: 12pt;\">(du lundi au vendredi de 8h30 \u00e0 17h)<\/span><\/span><\/li><\/ul><p><strong><span style=\"color: #ed1164;\">Enfant<\/span><\/strong><br \/><strong>H\u00f4pital Gatien de Clocheville<\/strong><\/p><ul><li>T\u00e9l : <span style=\"color: #ed1164; font-size: 14pt;\"><strong>02 47 47 47 54<\/strong><\/span><\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-131b820 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"131b820\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-18066f6c\" data-id=\"18066f6c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-618272bf elementor-widget elementor-widget-image\" data-id=\"618272bf\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"99\" src=\"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-content\/uploads\/sites\/15\/2024\/06\/recherche-foie-300x99.jpg\" class=\"attachment-medium size-medium wp-image-2309\" alt=\"\" srcset=\"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-content\/uploads\/sites\/15\/2024\/06\/recherche-foie-300x99.jpg 300w, https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-content\/uploads\/sites\/15\/2024\/06\/recherche-foie-1024x336.jpg 1024w, https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-content\/uploads\/sites\/15\/2024\/06\/recherche-foie-768x252.jpg 768w, https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-content\/uploads\/sites\/15\/2024\/06\/recherche-foie-915x300.jpg 915w, https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-content\/uploads\/sites\/15\/2024\/06\/recherche-foie.jpg 1142w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">RECHERCHE<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6c7ae12 elementor-widget elementor-widget-toggle\" data-id=\"6c7ae12\" data-element_type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1131\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1131\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\"><span style=\"text-transform: uppercase\"><strong>Protocoles en cours<\/strong><\/span><\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1131\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1131\"><p>Un protocole de recherche est une \u00e9tude scientifique men\u00e9e sur des patients afin d\u2019\u00e9valuer l\u2019efficacit\u00e9 et la s\u00e9curit\u00e9 d\u2019une ou plusieurs interventions m\u00e9dicales telles que les m\u00e9dicaments, les dispositifs m\u00e9dicaux ou encore les th\u00e9rapies comportementales.<\/p><p>Depuis plus de 5 ans, la participation aux protocoles de recherche acad\u00e9miques et industriels s\u2019est largement accrue pour le Centre de R\u00e9f\u00e9rence Constitutif des Microangiopathies Thrombotiques. Vous pouvez participer \u00e0 une \u00e9tude clinique pour aider la recherche. Parlez-en \u00e0 votre m\u00e9decin traitant, puis renseignez vous aupr\u00e8s des infirmiers de recherche clinique du centre :<\/p><ul><li><b>Infirmiers de recherche clinique N\u00e9phrologie \u2013 Transplantation r\u00e9nale : <\/b><span style=\"color: #ed1164;\"><b>02 34 37 96 78<\/b><\/span><\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cf53f43 elementor-widget elementor-widget-toggle\" data-id=\"cf53f43\" data-element_type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2171\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-2171\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\"><span style=\"text-transform: uppercase\"><strong>PROJETS DE RECHERCHES CLINIQUES<\/strong><\/span><\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2171\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-2171\"><p><b>RECRUTEMENT (<\/b><b>actif<\/b><b>)<\/b><\/p><p><b>Personalized Spacing of <\/b><b>Eculizumab<\/b><b> Infusions Based on Therapeutic Pharmacological Monitoring (<\/b><b>EspacECU<\/b><b>) <\/b>&#8211; Syndrome h\u00e9molytique et ur\u00e9mique atypique<\/p><p>Pour plus d\u2019informations : <a href=\"https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT04859608\" target=\"_blank\" rel=\"noopener\">https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT04859608<\/a><\/p><p><b>Efficacy of a Personalized <\/b><b>Caplacizumab<\/b><b> Regimen Based on ADAMTS13 Activity Monitoring in Adult <\/b><b>aTTP<\/b><b> (CAPLAVIE)<\/b> &#8211; Purpura thrombotique thrombocytop\u00e9nique acquise<\/p><p>Pour plus d\u2019informations : <a href=\"https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT04720261\" target=\"_blank\" rel=\"noopener\">https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT04720261<\/a><\/p><p><b>French National Cohort MATRIX &#8220;Renal and Systemic Thrombotic <\/b><b>Microangiopathy<\/b><b>&#8221; (MATRIX)<\/b><\/p><p>Pour plus d\u2019informations : <a href=\"https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT05991245\" target=\"_blank\" rel=\"noopener\">https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT05991245<\/a><\/p><p>\u00a0<b>A New Breath for Malignant Hypertension: Implementation of the HAMA Cohort (HAMA) <\/b>&#8211; Hypertension art\u00e9rielle maligne<\/p><p>Pour plus d\u2019informations : <a href=\"https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT03755726\" target=\"_blank\" rel=\"noopener\">https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT03755726<\/a><\/p><p><b>Interrupters<\/b><b> of <\/b><b>VAscular<\/b> <b>daMAge<\/b><b> in <\/b><b>Malignant<\/b><b> Hypertension (IVAMA)<\/b> &#8211; Hypertension art\u00e9rielle maligne<\/p><p>Pour plus d\u2019informations : <a href=\"https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT04991077\" target=\"_blank\" rel=\"noopener\">https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT04991077<\/a><\/p><p><b>Atypical Hemolytic-Uremic Syndrome (<\/b><b>aHUS<\/b><b>) Registry<\/b> &#8211; Syndrome h\u00e9molytique et ur\u00e9mique atypique<\/p><p>(Alexion Pharmaceuticals, Inc)<\/p><p>Pour plus d\u2019informations : <a href=\"https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT01522183\" target=\"_blank\" rel=\"noopener\">https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT01522183<\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-108122f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"108122f\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-068c693\" data-id=\"068c693\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8f16b33 elementor-widget elementor-widget-image\" data-id=\"8f16b33\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"126\" src=\"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-content\/uploads\/sites\/15\/2024\/06\/publications-foie-300x126.jpg\" class=\"attachment-medium size-medium wp-image-2310\" alt=\"publications\" srcset=\"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-content\/uploads\/sites\/15\/2024\/06\/publications-foie-300x126.jpg 300w, https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-content\/uploads\/sites\/15\/2024\/06\/publications-foie.jpg 720w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">PUBLICATIONS<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7c42ee2 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7c42ee2\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4c69160\" data-id=\"4c69160\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-544932c elementor-widget elementor-widget-toggle\" data-id=\"544932c\" data-element_type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-8831\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-8831\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\"><span style=\"text-transform: uppercase\"><strong>Publications 2021-2024<\/strong><\/span><\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-8831\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-8831\"><ul><li><b>2021 :<\/b><\/li><\/ul><p style=\"padding-left: 40px;\"><b>SGLT2 <\/b><b>inhibitors<\/b><b>: A new <\/b><b>era<\/b><b> for <\/b><b>our<\/b><b> patients. <\/b><b>Halimi JM<\/b>. Nephrol Ther. 2021 Jun;17(3):143-148.<\/p><p style=\"padding-left: 40px;\"><b>Infection in Patients with Suspected Thrombotic Microangiopathy Based on Clinical Presentation. <\/b>Thoreau B, von Tokarski F, Bauvois A, Bayer G, Barbet C, Cloarec S, M\u00e9rieau E, Lachot S, Garot D, Bernard L, Gyan E, Perrotin F, Pouplard C, Maillot F, Gatault P, Sautenet B, Rusch E, Fr\u00e9meaux-Bacchi V, Vigneau C, Fakhouri F,\u00a0<b>Halimi JM. <\/b>Clin J Am Soc Nephrol. 2021 Sep;16(9):1355-1364.<\/p><ul><li><b>2022 :<\/b><\/li><\/ul><p style=\"padding-left: 40px;\"><b>What is the impact of blood pressure on neurological symptoms and the risk of ESKD in primary and secondary thrombotic microangiopathies based on clinical presentation: a retrospective study<\/b>.<b> Halimi JM<\/b>, Thoreau B, von Tokarski F, Bauvois A, Gueguen J, Goin N, Barbet C, Cloarec S, M\u00e9rieau E, Lachot S, Garot D, Lemaignen A, Gyan E, Perrotin F, Pouplard C, Maillot F, Gatault P, Sautenet B, Rusch E, Fr\u00e9meaux-Bacchi V, Vigneau C, Bayer G, Fakhouri F. BMC Nephrol. 2022 Jan 20;23(1):39.<\/p><p style=\"padding-left: 40px;\"><b>Immune-mediated thrombotic thrombocytopenic purpura prognosis is affected by blood pressure. <\/b>Joseph A, Eloit M, Azoulay E, Kaplanski G, Provot F, Presne C, Wynckel A, Grang\u00e9 S, Rondeau \u00c9, P\u00e8ne F, Delmas Y, Lautrette A, Barbet C, Mousson C, Coindre JP, Perez P, Jamme M, Augusto JF, Poullin P, Jacobs F, El Karoui K, Vigneau C, Ulrich M, Kanouni T, Le Quintrec M, Hamidou M, Ville S, Charvet-Rumpler A, Ojeda-Uribe M, Godmer P, Fremeaux-Bacchi V, Veyradier A,\u00a0<b>Halimi JM<\/b>, Coppo P. Res Pract Thromb Haemost. 2022 May 18;6(4):e12702. doi: 10.1002\/rth2.12702. eCollection 2022 May.PMID:\u00a035599703\u00a0<\/p><p style=\"padding-left: 40px;\"><b>Predictive Scores for Early Identification of Immune-Mediated Thrombotic Thrombocytopenic Purpura: Room for Improvement? <\/b>Joseph A, Brilland B, Burguet L, Eloit M, Fage N, Augusto JF, Delmas Y, Veyradier A,\u00a0<b>Halimi JM<\/b>, Coppo P. Kidney Int Rep. 2022 Sep 23;7(11):2541-2542. doi: 10.1016\/j.ekir.2022.09.016. eCollection 2022 Nov.PMID:\u00a036531867<\/p><ul><li><b>2023 :<\/b><\/li><\/ul><p style=\"padding-left: 40px;\"><b>Predictors of acute ischemic cerebral lesions in immune-mediated thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. <\/b>Neuman L, Joseph A, Bouzid R, Lescroart M, Mariotte E, Ederhy S, Tuffet S, Baudel JL, Benhamou Y, Galicier L, Grang\u00e9 S, Prov\u00f4t F, Neel A, P\u00e8ne F, Delmas Y, Presne C, Poullin P, Wynckel A, Perez P, Barbet C,\u00a0<b>Halimi JM<\/b>, Chatelet V, Rebibou JM, Ojeda-Uribe M, Vigneau C, Mesnard L, Veyradier A, Azoulay E, Coppo P, Chabriat H; participants to the Prospective Multicenter MATRISK study. J Neurol. 2023 Oct;270(10):5023-5033. doi: 10.1007\/s00415-023-11830-y. Epub 2023 Jul 1.PMID:\u00a037392208<\/p><p style=\"padding-left: 40px;\"><b><br \/>Thrombotic microangiopathy associated with anticancer and immune system targeting drugs: New insights from real-world data using the WHO pharmacovigilance database. <\/b>Largeau B, Thoreau B, Grang\u00e9 S, Jonville-B\u00e9ra AP,\u00a0<b>Halimi JM. <\/b>J Intern Med. 2023 Nov;294(5):665-678. doi: 10.1111\/joim.13703. Epub 2023 Aug 4.PMID:\u00a037538031<\/p><p style=\"padding-left: 40px;\"><b>Thrombotic microangiopathies after kidney transplantation in modern era: nosology based on chronology. <\/b>Von Tokarski F, Fillon A, Maisons V, Thoreau B, Bayer G, Gatault P, Longuet H, Sautenet B, Buchler M, Vigneau C, Fakhouri F,\u00a0<b>Halimi JM. <\/b>BMC Nephrol. 2023 Sep 20;24(1):278. doi: 10.1186\/s12882-023-03326-8.PMID:\u00a037730583\u00a0<\/p><p style=\"padding-left: 40px;\"><b>Intussusception as a complication of idiopathic nephrotic syndrome. <\/b>Dreant F, Sautenet B, Barbet C,\u00a0<b>Halimi JM. <\/b>Kidney Int. 2023 Oct;104(4):861. doi: 10.1016\/j.kint.2023.04.032.PMID:\u00a037739622\u00a0<\/p><ul><li><b>2024 :<\/b><\/li><\/ul><p style=\"padding-left: 40px;\"><b>Chronic<\/b> <b>cardiovascular-kidney<\/b> <b>disorder<\/b><b>: a new <\/b><b>conceptual<\/b> <b>framework<\/b><b>. <\/b>Zoccali C, Mallamaci F, <b>Halimi JM<\/b>, Rossignol P, Sarafidis P, De Caterina R, Giugliano R, Zannad F. Nat Rev Nephrol. 2024 Apr;20(4):201-202. doi: 10.1038\/s41581-023-00789-8. Epub 2023 Nov 15. PMID: 37968510<\/p><p style=\"padding-left: 40px;\"><b>Assessment<\/b><b> of <\/b><b>epidemiology<\/b><b> and <\/b><b>outcomes<\/b><b> of <\/b><b>adult<\/b><b> patients with <\/b><b>kidney-limited<\/b> <b>thrombotic<\/b> <b>microangiopathies<\/b><b>. <\/b><b>Maisons V<\/b>, Duval A, Mesnard L, Frimat M, Fakhouri F, Grang\u00e9 S, Servais A, Cartery C, <b>Fauchier L<\/b>, Coppo P, Titeca-Beauport D, Fage N, Delmas Y, Qu\u00e9rard AH, Seret G, Bobot M, Le Quintrec M, Ville S, von Tokarski F, Chauvet S, Wynckel A, Martins M, Schurder J, <b>Barbet C, <\/b><b>Sautenet<\/b><b> B, <\/b><b>Gatault<\/b><b> P<\/b>, <b>Caillard<\/b><b> S,<\/b> Vuiblet V, <b>Halimi JM<\/b>; MATRIX Consortium Group. Kidney Int. 2024 Feb 29:S0085-2538(24)00170-4. doi: 10.1016\/j.kint.2024.02.014. Online ahead of print. PMID: 38431217<\/p><p style=\"padding-left: 40px;\"><b>Neutrophil<\/b><b> activation in patients <\/b><b>treated<\/b><b> with <\/b><b>endovascular<\/b> <b>therapy<\/b> <b>is<\/b> <b>associated<\/b><b> with <\/b><b>unfavorable<\/b> <b>outcomes<\/b><b> and <\/b><b>mitigated<\/b><b> by <\/b><b>intravenous<\/b> <b>thrombolysis<\/b><b>. <\/b>Ma\u00efer B, Di Meglio L, Desilles JP, Solo Nomenjanahary M, Delvoye F, Kyheng M, Boursin P, Ollivier V, Dupont S, Rambaud T, Hamdani M, Labreuche J, Blanc R, Piotin M, <b>Halimi JM<\/b>, Mazighi M, Ho-Tin-Noe B; NEUTROSTROKE investigators. J Neurointerv Surg. 2024 Jan 12;16(2):131-137. doi: 10.1136\/jnis-2022-020020. PMID: 37068937<\/p><p style=\"padding-left: 40px;\"><b>A <\/b><b>European<\/b> <b>Renal<\/b><b> Association (ERA) synopsis for <\/b><b>nephrology<\/b><b> practice of the 2023 <\/b><b>European<\/b><b> Society of Hypertension (ESH) Guidelines for the Management of <\/b><b>Arterial<\/b><b> Hypertension. <\/b>Sarafidis P, Schmieder R, Burnier M, Persu A, Januszewicz A, <b>Halimi JM<\/b>, Arici M, Ortiz A, Wanner C, Mancia G, Kreutz R. Nephrol Dial Transplant. 2024 Feb 14:gfae041. doi: 10.1093\/ndt\/gfae041. Online ahead of print. PMID: 38365947<\/p><p style=\"padding-left: 40px;\"><b>Eculizumab<\/b><b> dose <\/b><b>tapering<\/b> <b>should<\/b> <b>take<\/b> <b>into<\/b> <b>account<\/b><b> the <\/b><b>nonlinearity<\/b><b> of <\/b><b>its<\/b> <b>pharmacokinetics<\/b><b>. <\/b><b>Le Tilly O, <\/b><b>Gatault<\/b><b> P, <\/b><b>Semlali<\/b><b> S<\/b>, Sberro-Soussan R, Passot C, Bertrand D, <b>Desvignes<\/b><b> C, <\/b><b>Caillard<\/b><b> S, <\/b><b>Paintaud<\/b><b> G, Halimi JM, <\/b><b>Ternant<\/b><b> D. <\/b>Br J Clin Pharmacol. 2024 Feb 19. doi: 10.1111\/bcp.16019. Online ahead of print. PMID: 38373846<\/p><p style=\"padding-left: 40px;\">Author Correction: <b>Chronic<\/b> <b>cardiovascular-kidney<\/b> <b>disorder<\/b><b>: a new <\/b><b>conceptual<\/b> <b>framework<\/b>. Zoccali C, Mallamaci F, <b>Halimi JM<\/b>, Rossignol P, Sarafidis P, De Caterina R, Giugliano R, Zannad F. Nat Rev Nephrol. 2024 Apr;20(4):266. doi: 10.1038\/s41581-024-00805-5. PMID: 38191676<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1bb59a30 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1bb59a30\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3cc36e06\" data-id=\"3cc36e06\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1c211fa9 elementor-widget elementor-widget-image\" data-id=\"1c211fa9\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"263\" src=\"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-content\/uploads\/sites\/15\/2023\/02\/enseignement-300x263-1.png\" class=\"attachment-medium size-medium wp-image-365\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">ENSEIGNEMENT et formation<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1f8da296 elementor-widget elementor-widget-toggle\" data-id=\"1f8da296\" data-element_type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-5291\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-5291\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\"><span style=\"text-transform: uppercase\"><strong>Enseignement et formation<\/strong><\/span><\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-5291\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-5291\"><p><u><b>DIPL\u00d4MES UNIVERSITAIRES (DU)<\/b><\/u><\/p><ul><li><b> DU \u00ab <\/b><b>Immuno-H\u00e9matologie<\/b><b> Et M\u00e9decine Interne \u00bb. <\/b><\/li><\/ul><p style=\"padding-left: 40px;\"><a href=\"https:\/\/marih.fr\/formation\/du_immuno_hematologie_et_medecine_interne_\/\" target=\"_blank\" rel=\"noopener\">DU \u00ab <\/a><a href=\"https:\/\/marih.fr\/formation\/du_immuno_hematologie_et_medecine_interne_\/\">Immuno-H\u00e9matologie<\/a><a href=\"https:\/\/marih.fr\/formation\/du_immuno_hematologie_et_medecine_interne_\/\"> et M\u00e9decine Interne \u00bb &#8211; <\/a><a href=\"https:\/\/marih.fr\/formation\/du_immuno_hematologie_et_medecine_interne_\/\">MaRIH<\/a><a href=\"https:\/\/marih.fr\/formation\/du_immuno_hematologie_et_medecine_interne_\/\"> &#8211; Fili\u00e8re de sant\u00e9 Maladies Rares <\/a><a href=\"https:\/\/marih.fr\/formation\/du_immuno_hematologie_et_medecine_interne_\/\">Immuno-H\u00e9matologiques<\/a><\/p><ul><li><b>DU \u00ab MAT Et Autres Maladies Immunologiques De L\u2019h\u00e9mostase \u00bb. <\/b><\/li><\/ul><p style=\"padding-left: 40px;\"><a href=\"https:\/\/marih.fr\/formation\/du-mat-et-autres-maladies-immunologiques-de-lhemostase\/\" target=\"_blank\" rel=\"noopener\">DU &#8220;MAT et autres maladies immunologiques de l\u2019h\u00e9mostase&#8221; &#8211; <\/a><a href=\"https:\/\/marih.fr\/formation\/du-mat-et-autres-maladies-immunologiques-de-lhemostase\/\">MaRIH<\/a><a href=\"https:\/\/marih.fr\/formation\/du-mat-et-autres-maladies-immunologiques-de-lhemostase\/\"> &#8211; Fili\u00e8re de sant\u00e9 Maladies Rares <\/a><a href=\"https:\/\/marih.fr\/formation\/du-mat-et-autres-maladies-immunologiques-de-lhemostase\/\">Immuno-H\u00e9matologiques<\/a><\/p><p><u><b>LES FORMATIONS POST-UNIVERSITAIRES<\/b><\/u><\/p><ul><li style=\"list-style-type: none;\"><ul><li><b>MOOC <\/b><b>MaRIH<\/b><b> : <\/b>enseignement ouverts aux professionnels de sant\u00e9 souhaitant approfondir leur formation initiale.<br \/><a href=\"https:\/\/marih.fr\/formation\/mooc_marih\/\" target=\"_blank\" rel=\"noopener\">MOOC <\/a><a href=\"https:\/\/marih.fr\/formation\/mooc_marih\/\">MaRIH<\/a><a href=\"https:\/\/marih.fr\/formation\/mooc_marih\/\"> &#8211; <\/a><a href=\"https:\/\/marih.fr\/formation\/mooc_marih\/\">MaRIH<\/a><a href=\"https:\/\/marih.fr\/formation\/mooc_marih\/\"> &#8211; Fili\u00e8re de sant\u00e9 Maladies Rares <\/a><a href=\"https:\/\/marih.fr\/formation\/mooc_marih\/\">Immuno-H\u00e9matologiques<\/a><\/li><\/ul><\/li><\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-63b13735 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"63b13735\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3889e675\" data-id=\"3889e675\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6a5f8656 elementor-widget elementor-widget-image\" data-id=\"6a5f8656\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"212\" src=\"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-content\/uploads\/sites\/15\/2023\/02\/outils-300x212-1.png\" class=\"attachment-medium size-medium wp-image-367\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">OUTILS<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-632bf32c elementor-widget elementor-widget-toggle\" data-id=\"632bf32c\" data-element_type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1661\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1661\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\"><span style=\"text-transform: uppercase\"><strong>Protocoles Nationaux de Diagnostic et de Soins (PNDS) <\/strong><\/span><\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1661\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1661\"><h4>D\u00e9finition HAS :<\/h4><p><em><strong>L\u2019objectif d\u2019un PNDS<\/strong> est d\u2019expliciter aux professionnels concern\u00e9s la prise en charge diagnostique et th\u00e9rapeutique optimale actuelle et le parcours de soins d\u2019un patient atteint d\u2019une maladie rare donn\u00e9e. Il a pour but d\u2019optimiser et d\u2019harmoniser la prise en charge et le suivi de la maladie rare sur l\u2019ensemble du territoire.<\/em><\/p><p><em>Le PNDS peut servir de r\u00e9f\u00e9rence au m\u00e9decin traitant (m\u00e9decin d\u00e9sign\u00e9 par le patient aupr\u00e8s de la Caisse d\u2019Assurance Maladie) en concertation avec le m\u00e9decin sp\u00e9cialiste notamment au moment d\u2019\u00e9tablir le protocole de soins conjointement avec le m\u00e9decin conseil et le patient, dans le cas d&#8217;une demande d&#8217;exon\u00e9ration du ticket mod\u00e9rateur au titre d&#8217;une affection hors liste.<\/em><\/p><ul><li><b>Syndrome H\u00e9molytique et Ur\u00e9mique <\/b>(f\u00e9vrier 2021) &#8211;<a href=\"https:\/\/www.has-sante.fr\/upload\/docs\/application\/pdf\/2021-02\/syndrome_lipodystrophique_de_dunnigan_-_pnds_2021-02-10_13-00-54_570.pdf\" target=\"_blank\" rel=\"noopener\"> Proposition de pr\u00e9sentation des documents de recommandations et r\u00e9f\u00e9rences professionnelles (has-sante.fr)<\/a><\/li><li><b>Purpura thrombop\u00e9nique immunologique <\/b>(mai 2017) &#8211; <a href=\"https:\/\/www.has-sante.fr\/upload\/docs\/application\/pdf\/2017-06\/dir36\/pnds-_purpura_thrombopenique_immunologique.pdf\" target=\"_blank\" rel=\"noopener\">PNDS PTI Finalis\u00e9 21.5.2017 (has-sante.fr)<\/a><\/li><li><b>Purpura thrombotique <\/b><b>thrombocytop\u00e9nique<\/b> (mars 2023) &#8211; <a href=\"https:\/\/www.has-sante.fr\/upload\/docs\/application\/pdf\/2022-10\/pnds_ptt_26092022_final.pdf\" target=\"_blank\" rel=\"noopener\">PNDS_Pathologie<\/a><a href=\"https:\/\/www.has-sante.fr\/upload\/docs\/application\/pdf\/2022-10\/pnds_ptt_26092022_final.pdf\"> (has-sante.fr)<\/a><\/li><\/ul><h4>Recommandations de Bonnes Pratiques<\/h4><ul><li><b>ISTH guidelines for the <\/b><b>diagnosis<\/b><b> of <\/b><b>thrombotic<\/b> <b>thrombocytopenic<\/b><b> purpura <\/b>(juin 2020). <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/epdf\/10.1111\/jth.15006\" target=\"_blank\" rel=\"noopener\">ISTH guidelines for the diagnosis of thrombotic thrombocytopenic purpura (wiley.com)<\/a><\/li><li><b>ISTH guidelines for the <\/b><b>treatment<\/b><b> of <\/b><b>thrombotic<\/b> <b>thrombocytopenic<\/b><b> purpura <\/b>(juillet 2020). <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/epdf\/10.1111\/jth.15010\" target=\"_blank\" rel=\"noopener\">ISTH guidelines for treatment of thrombotic thrombocytopenic purpura (wiley.com)<\/a><\/li><\/ul><h5>Carte d&#8217;urgence<\/h5><p>Au cours du congr\u00e8s des urgences de juin 2018, la fili\u00e8re de sant\u00e9 sp\u00e9cialis\u00e9e dans les maladies rares immuno-h\u00e9matologiques, MaRIH, a eu l&#8217;opportunit\u00e9 de d\u00e9voiler, aux c\u00f4t\u00e9s d&#8217;autres fili\u00e8res, les toutes nouvelles cartes d&#8217;urgence pour les maladies rares.<\/p><p>Ces documents, con\u00e7us \u00e0 l&#8217;intention aussi bien des professionnels de sant\u00e9 que des patients, fournissent des directives \u00e0 suivre en cas de situation d&#8217;urgence. \u00c9labor\u00e9es par des m\u00e9decins experts, ces cartes sont d\u00e9sormais accessibles dans les centres de r\u00e9f\u00e9rence MaRIH.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ab195bd elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ab195bd\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-16e05de1\" data-id=\"16e05de1\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4062a094 elementor-widget elementor-widget-image\" data-id=\"4062a094\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"192\" src=\"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-content\/uploads\/sites\/15\/2023\/02\/liens-300x192-1.png\" class=\"attachment-medium size-medium wp-image-370\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">LIENS<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3250ded5 elementor-widget elementor-widget-toggle\" data-id=\"3250ded5\" data-element_type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-8441\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-8441\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\"><span style=\"text-transform: uppercase\"><strong>Liens<\/strong><\/span><\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-8441\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-8441\"><h4>Fili\u00e8re de sant\u00e9 :<\/h4><table style=\"border-collapse: collapse; width: 100%;\"><tbody><tr><td style=\"width: 20%;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-2336 size-full\" src=\"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-content\/uploads\/sites\/15\/2024\/06\/logo-MaRIH.png\" alt=\"Logo MaRIH\" width=\"230\" height=\"109\" \/><\/td><td style=\"width: 80%; padding-left: 40px;\">La fili\u00e8re MaRIH a pour principale mission de d\u00e9velopper des synergies entre acteurs de la prise en charge des maladies rares. Cette mission se d\u00e9coupe en plusieurs axes :<\/td><\/tr><\/tbody><\/table><ul><li>Am\u00e9liorer la rapidit\u00e9 du diagnostic et la qualit\u00e9 du parcours de soin des patients<\/li><li>Informer et accompagner les patients<\/li><li>Former les professionnels m\u00e9dicaux et param\u00e9dicaux<\/li><li>Dynamiser et coordonner la recherche fondamentale et clinique<\/li><\/ul><p style=\"padding-left: 40px;\"><i><span style=\"color: #2bb718;\"><strong>&gt;&gt;<\/strong><\/span> <span style=\"color: #2bb718;\"><strong>+ d\u2019infos sur <\/strong><\/span><\/i><i><a href=\"https:\/\/www.filfoie.com\/\">FILFOIE : <\/a><\/i><i><a href=\"https:\/\/marih.fr\/\" target=\"_blank\" rel=\"noopener\">Accueil &#8211; MaRIH &#8211; Fili\u00e8re de sant\u00e9 Maladies Rares Immuno-H\u00e9matologiques<\/a><\/i><i>.<\/i><\/p><h4>Soci\u00e9t\u00e9s Savantes :<\/h4><ul><li>Alliance nationale pour les sciences de la vie et de la sant\u00e9 (AVIESAN). <a href=\"http:\/\/www.aviesan.fr\/\">www.<\/a><u><a href=\"http:\/\/www.aviesan.fr\/\" target=\"_blank\" rel=\"noopener\">aviesan<\/a><\/u><u><a href=\"http:\/\/www.aviesan.fr\/\">.fr<\/a><\/u><\/li><li>Soci\u00e9t\u00e9 Fran\u00e7aise de Greffe de Moelle et de Th\u00e9rapie Cellulaire (SFGM). <a href=\"https:\/\/www.sfgm-tc.com\/\" target=\"_blank\" rel=\"noopener\">Accueil (sfgm-tc.com)<\/a><\/li><li>Soci\u00e9t\u00e9 Fran\u00e7aise d\u2019H\u00e9matologie (SFH). <a href=\"https:\/\/sfh.hematologie.net\/accueil\" target=\"_blank\" rel=\"noopener\">Accueil | Soci\u00e9t\u00e9 Fran\u00e7aise d\u2019H\u00e9matologie (hematologie.net)<\/a><\/li><li>Soci\u00e9t\u00e9 Fran\u00e7aise d\u2019Immunologie (SFI). <a href=\"https:\/\/immunology.fr\/fr\/\" target=\"_blank\" rel=\"noopener\">Soci\u00e9t\u00e9 Fran\u00e7aise d\u2019Immunologie \u2022 Soci\u00e9t\u00e9 Fran\u00e7aise d&#8217;Immunologie (immunology.fr)<\/a><\/li><li>Soci\u00e9t\u00e9 d\u2019H\u00e9matologie et d\u2019Immunologie P\u00e9diatrique (SHIP). <a href=\"https:\/\/www.ship-sofremip.com\/\" target=\"_blank\" rel=\"noopener\">Accueil &#8211; SHIP-SOFREMIP<\/a><\/li><li>Soci\u00e9t\u00e9 Francophone de N\u00e9phrologie Dialyse et Transplantation (SFNDT). <a href=\"https:\/\/www.sfndt.org\/\" target=\"_blank\" rel=\"noopener\">Soci\u00e9t\u00e9 Francophone de N\u00e9phrologie Dialyse et Transplantation (sfndt.org)<\/a><\/li><li>Soci\u00e9t\u00e9 Nationale Fran\u00e7aise de M\u00e9decine Interne (SNFMI). <a href=\"https:\/\/www.snfmi.org\/\" target=\"_blank\" rel=\"noopener\">SNFMI | Soci\u00e9t\u00e9 Nationale de M\u00e9decine Interne<\/a><\/li><li>Soci\u00e9t\u00e9 Fran\u00e7aise de Pneumologie de Langue Fran\u00e7aise (SPLF). <a href=\"https:\/\/splf.fr\/\" target=\"_blank\" rel=\"noopener\">accueil &#8211; Soci\u00e9t\u00e9 de Pneumologie de Langue Fran\u00e7aise (splf.fr)<\/a><\/li><\/ul><h4>Associations de patients :<\/h4><p>Retrouvez la liste des 15 associations de patients ainsi que leur pr\u00e9sentation ici <b>: <\/b><a href=\"https:\/\/marih.fr\/wp-content\/uploads\/2023\/07\/Livret-VF.pdf\" target=\"_blank\" rel=\"noopener\">Livret-VF.pdf (marih.fr)<\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Le Centre de r\u00e9f\u00e9rence constitutif est compos\u00e9 d\u2019une \u00e9quipe pluridisciplinaire sp\u00e9cialis\u00e9e dans la prise en charge des MicroAngiopathies Thrombotiques (MAT). Ses missions : Assurer le diagnostic et la coordination des soins pour les patients (enfants et adultes) atteints de microangiopathies thrombotiques Coordonner et participer \u00e0 des projets de recherche (fondamentales, cliniques, \u00e9pid\u00e9miologiques) Promouvoir l\u2019enseignement et [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"Centre de R\u00e9f\u00e9rence Constitutif des MicroAngiopathies Thrombotiques (MAT)","_seopress_titles_desc":"Le Centre de r\u00e9f\u00e9rence constitutif est compos\u00e9 d\u2019une \u00e9quipe pluridisciplinaire sp\u00e9cialis\u00e9e dans la prise en charge des MicroAngiopathies Thrombotiques (MAT). \r\n","_seopress_robots_index":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"publishpress_future_action":{"enabled":false,"date":"2026-04-23 23:58:47","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"_links":{"self":[{"href":"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-json\/wp\/v2\/pages\/2334"}],"collection":[{"href":"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-json\/wp\/v2\/comments?post=2334"}],"version-history":[{"count":25,"href":"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-json\/wp\/v2\/pages\/2334\/revisions"}],"predecessor-version":[{"id":2361,"href":"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-json\/wp\/v2\/pages\/2334\/revisions\/2361"}],"wp:attachment":[{"href":"https:\/\/www.chu-tours.fr\/pemr-cvl\/wp-json\/wp\/v2\/media?parent=2334"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}