{"id":39,"date":"2024-12-09T14:15:06","date_gmt":"2024-12-09T13:15:06","guid":{"rendered":"https:\/\/www.chu-tours.fr\/mat\/?page_id=39"},"modified":"2025-01-16T15:36:31","modified_gmt":"2025-01-16T14:36:31","slug":"obtention-du-financement-projet-de-recherche-airg-france-2024","status":"publish","type":"page","link":"https:\/\/www.chu-tours.fr\/mat\/obtention-du-financement-projet-de-recherche-airg-france-2024\/","title":{"rendered":"Obtention du financement :  projet de recherche AIRG-France 2024"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"39\" class=\"elementor elementor-39\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-30174cb e-flex e-con-boxed e-con e-parent\" data-id=\"30174cb\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-09dc7bd elementor-widget elementor-widget-image\" data-id=\"09dc7bd\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 15-07-2024 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"300\" height=\"72\" src=\"https:\/\/www.chu-tours.fr\/mat\/wp-content\/uploads\/sites\/17\/2024\/12\/logo-AIRG-300x72.png\" class=\"attachment-medium size-medium wp-image-42\" alt=\"\" srcset=\"https:\/\/www.chu-tours.fr\/mat\/wp-content\/uploads\/sites\/17\/2024\/12\/logo-AIRG-300x72.png 300w, https:\/\/www.chu-tours.fr\/mat\/wp-content\/uploads\/sites\/17\/2024\/12\/logo-AIRG.png 415w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-176f0f2 e-flex e-con-boxed e-con e-parent\" data-id=\"176f0f2\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c95c9b2 elementor-widget elementor-widget-text-editor\" data-id=\"c95c9b2\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 15-07-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p><b>Influence du sexe f\u00e9minin et du genre sur le profil clinique, biologique, la r\u00e9ponse aux traitements et le devenir des patients ayant une microangiopathie thrombotique (MAT) d\u2019origine g\u00e9n\u00e9tique ou non &#8211; Cohorte MATRIX <\/b><\/p><p>Jean-Michel Halimi, Tours \u2013 INSERM UMR 1327 ISCHEMIA \u00ab Membrane signaling and inflammation in reperfusion injuries \u00bb.<\/p><p style=\"text-align: justify;\"><b>R\u00e9sum\u00e9<\/b> : Les microangiopathies thrombotiques (MAT) constituent un groupe de maladies rares et graves dont le pronostic r\u00e9nal demeure sombre. Elles peuvent \u00eatre associ\u00e9es \u00e0 des variants g\u00e9n\u00e9tiques pathog\u00e8nes. Dans la majorit\u00e9 des cas, les MAT sont suspect\u00e9es \u00e0 partir de donn\u00e9es biologiques mais la preuve histologique est rarement pr\u00e9sente. Pour r\u00e9pondre \u00e0 cette difficult\u00e9, nous avons d\u00e9velopp\u00e9 l\u2019une des plus grandes cohortes mondiales de patients ayant une MAT prouv\u00e9e par biopsie r\u00e9nale (1072 patients (MATRIX\u00a0: NCT05991245). Il existe une relation mal comprise entre MAT et sexe f\u00e9minin. Les femmes sont \u00e0 plus haut risque de d\u00e9velopper une MAT de type SHU atypique\u00a0ou auto-immune \u00e0 l\u2019\u00e2ge adulte et de PTT dans un contexte de grossesse. Mais de nombreuses questions demeurent que notre projet va explorer\u00a0: l\u2019influence du sexe f\u00e9minin et du genre sur l\u2019incidence des MAT, la pr\u00e9sentation clinique et biologique des MAT, les causes de MAT, particuli\u00e8rement celles associ\u00e9es aux variants g\u00e9n\u00e9tiques et les MAT \u00ab\u00a0secondaires\u00a0\u00bb moins \u00e9tudi\u00e9es, la prise en charge, le devenir des patientes et la r\u00e9ponse th\u00e9rapeutique. Ce type d\u2019\u00e9tude n\u2019a jamais \u00e9t\u00e9 r\u00e9alis\u00e9 chez des patients ayant une MAT histologiquement prouv\u00e9e. Les r\u00e9sultats permettront de d\u00e9pister les biais de prise en charge li\u00e9s au genre, mieux comprendre la relation entre sexe f\u00e9minin et les m\u00e9canismes de MAT et am\u00e9liorer leur prise en charge.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Influence du sexe f\u00e9minin et du genre sur le profil clinique, biologique, la r\u00e9ponse aux traitements et le devenir des patients ayant une microangiopathie thrombotique (MAT) d\u2019origine g\u00e9n\u00e9tique ou non &#8211; Cohorte MATRIX Jean-Michel Halimi, Tours \u2013 INSERM UMR 1327 ISCHEMIA \u00ab Membrane signaling and inflammation in reperfusion injuries \u00bb. R\u00e9sum\u00e9 : Les microangiopathies thrombotiques [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":395,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"publishpress_future_action":{"enabled":false,"date":"2026-04-13 12:15:37","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"_links":{"self":[{"href":"https:\/\/www.chu-tours.fr\/mat\/wp-json\/wp\/v2\/pages\/39"}],"collection":[{"href":"https:\/\/www.chu-tours.fr\/mat\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.chu-tours.fr\/mat\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.chu-tours.fr\/mat\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.chu-tours.fr\/mat\/wp-json\/wp\/v2\/comments?post=39"}],"version-history":[{"count":7,"href":"https:\/\/www.chu-tours.fr\/mat\/wp-json\/wp\/v2\/pages\/39\/revisions"}],"predecessor-version":[{"id":496,"href":"https:\/\/www.chu-tours.fr\/mat\/wp-json\/wp\/v2\/pages\/39\/revisions\/496"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.chu-tours.fr\/mat\/wp-json\/wp\/v2\/media\/395"}],"wp:attachment":[{"href":"https:\/\/www.chu-tours.fr\/mat\/wp-json\/wp\/v2\/media?parent=39"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}